Pathology of GIT: UC and Crohn's disease Flashcards
(36 cards)
Crohn’s disease is thought to go through the ______ pathway and cause the activation of ______ (inflammatory cell) leading to the formation of histolytic components such as granulomas
TNF pathway leading to the activation of macrophages = Crohn’s
(TH1)
what IBD is associated with liver abnormalities?
UC because it is associated with primary sclerosing cholangitis (P-ANCA)
in addition to necrotizing, large granulomas in TB caused colitis, you will also see longitudinal/transverse (direction) ulcers
transverse; Transverse = Tb
will see longitudinal ulcers in Crohn’s
What is the HLA association in Crohn’s disease
HLA DR7 and DQ4
what is the HLA association in UC
HLA DRB1
OCP’s is a risk factor for which occlusive cause of ischemic bowel disease
venous thrombosis
circumferential ulcers are seen in _______ caused colitis
NSAID related colitis
_________ is a toxigenic organism that can cause acute ischemic colitis
EHEC/STEC which will have pain, bloody diarrhea and hemolysis and renal failure (HUS)
which fluoroquinolone is associated with C. difficile colitis?
ciprofloxacin
mucosal and submucosal involvement with
UC; starts at rectum and has diffuse pattern of involvement (NOT FULL THICKNESS)
describe the ulcers seen in typhoid (enteric fever) in the GI
longitudinal ulcers typically over Peyer’s patches
a patient presents with weight loss and chronic diarrhea. she also has symptoms of intestinal obstruction. what is the most likely IBD
IBD's present with chronic diarrhea and weight loss intestinal obstruction (and malabsorption because Crohn's involves the ileum more commonly than UC) is more commonly seen with Crohn's due to the structures and ↑ wall thickening
_______ (IBD) will have granulomas
Crohn’s
granulomas are seen in ________
Crohn’s
what is the preferred method of diagnosing C. difficile caused pseudomembranous colitis/
stool tests:
- enzyme immunoassay for toxin A/B
- PCR for tcdB gene
stool culture takes 2-4 days so not often used
“string sign” on radiography is seen with ____
Crohn’s due to the wall thickening and strictures
subserosal infiltrating fat (creeping fat) is seen in ________ (IBD)
Crohn’s; it is serosal reaction to the transmural inflammation
pharmacologic administration of _______ (drugs) is associated with pseudomembranous colitis
↓ gastric acid secretion:
- PPI’s and H2 receptor inhibitors
bacteria that triggers dendritic cells and a activates the T helper and _____ pathway ultimately leading to activation of neutrophils is the proposed mechanism of _____ (IBD)
T helper (TH2) and IL-8 pathway causing activation of neutrophils is the proposed mechanism of Ulcerative Colitis
what are some associations of collagenous and lymphocytic colitis (microscopic colitis)
- NSAIDs
- celiac disease
- autoimmune: SLE, RA
what layers are affected in TB caused colitis?
superficial as opposed to in Crohn’s, it is transmural
pseudopolyps are seen in _____
UC; due to isolated islands of intervening regenerating mucosa bulge
______ (inflammatory cell) is seen in the epithelium of the crypt (cryptitis) or in the lumen (crypt abscess) and is associated with ____ (IBD)
neutrophils; UC
erythema nodosum is more commonly seen before/after the onset of GI symptoms and is seen more commonly in what IBD
erythema nodosum seen before the GI symptoms and more common in UC
