DNA Viruses Flashcards
(47 cards)
What is the common classification among herpes family of viruses?
dsDNA enveloped
What is the most common cause of intraoral inflammation of the gingiva and mucosa in a young newborn?
HSV-1 (typically from the mother)
What virus is responsible for a 25 year old with fever, headache, personality change, and hallucinations?
Desiminated HSV-1
– temporal lobe inflammation and hemorrhages
Where do HSV-1 and HSV-2 reside latently?
HSV-1 – usually trigeminal ganglia
HSV-2 – sacral ganglia
What test would you need to perform after you have aspired at vessicular lesion on a patient’s groin to identify?
Tzank Smear – look for multinucleated giant cells and intracellular inclusions – Cowdry Bodies
What is characteristics of HSV-2 infection?
painful groin vesiscular lesions with inguinal lymphadepathy
What family and characteristics is EBV?
Herpesfamily
dsDNA with envelope
What are unique pathology associated with EBV?
Infects B-cells via CD21 Receptor
- Infectious Mono
Immunocompromised
- Hodgkin’s Lymphoma – Reed-Sternburg Cells
- Burkitt Lymphoma – jaw/mandible lesions
- Nasopharyngeal Carcinoma (Asians)
- leukoplakia of the lateral tongue (HIV)
How can you tell strep pharyngitis/tonsillitis from infectious mononucleosis?
Strep – usually young children and resolves with amoxicillin/ampicillin
EBV – older children (teens) and will have posterior LAD and if started on amox/amp will develop macular rash
What are the diagnostic tests for EBV / Infectious Mononucleosis?
Monospot Test – heterophile antibodies that bind to horse RBC (REMEMBER B-CELLS)
What is a unique microscopic identifier of Infectious mononucleosis?
- Downey Cells, mostly CD8+ cells with indented nucleus
What family is CMV in and how is it classified?
Herpesfamily, dsDNA virus with envelop
What are the buzz words for congenital CMV infection?
- sensorineural HEARING LOSS in children
- “blue berry muffin rash” – petechiae rash
- intraventrical calcifications
- Hydrops Fetalis
- – its the most common congenital viral infection
What kind of symptoms in a patient that has a CD4 count below 50, if infected with CMV?
- CMV Retinitis
- Linear Ulcerations of esophagitis
- CMV Colitis
What is the causative agent if a 15 year old gets pharyngitis with posterior LAD, but negative Monospot Test?
- Strep
- - CMV (Owl’s Eye Appearance)
What family is varicella zoster in and classification?
Herpesfamily – dsDNA with evelope
What is unique characteristic of varicella in children?
“Dew drops on a rose” – type of rash
- Different stages of healing (KEY)
- fever/sweat
What are the pathologic factors in varicella?
- Latent in dorsal root ganglia
Immunocompromised
– dermatomal distribution
– postherpetic neurologia (painful area with or without rash several weeks/months)
Complication – varicella pneumonia (mortality)
What kind of vaccine is used for varicella?
Live Attenuated Virus
What is congenital Varicella consist of?
TORCH Infection
- blindness
- limb development inhibition (stubby)
- cutaneous scarring?
What families are HHV-6 and HHV-8 virus in and their classificiations?
Herpesfamily
dsDNA virus with envelope
What is the virus that affects young children (6m-2years) with a high fever followed by a rash that spares the face?
HHV-6 Roseola
– KEY – LACEY RASH, Spares the Face
Who is most commonly affected by HHV-8?
Immunosuppressed individuals
- elderly russian men
- african adults
What is the unique attribute of HHV-8 to look for clinically?
Immunosuppressed individuals
- Violacious Lesions of nose, extremities, and mucous membranes (hard palatte)
- Causes increased VEGF/vasculature
- Primary Effusion lymphoma
