Liver

Question 1

What is responsible for late onset diabetes, bronzing of the skin, impotence, joint disease?

Answer 1

Hemochromatosis

• • will have elevated liver function tests
• • increases serum ferritin / elevated % saturation transferrin

Question 2

How does cirrhosis of the liver affect circulation?

Answer 2

Portal flow back up, anastomoses through the left gastric (esphogeal) and rectal arteries.
– blood backs up in the portal system and spleen becomes enlarged with red pulp.

Question 3

What two lipid lowering drugs combined increase risk of gall stones?

Answer 3

Fibrates – Gemfibrozil – PPAR-gamma inducer
Bile Acid Binders – Cholestyramine
–Due to reducing the amount of bile acids in the bile and increase the amount of cholesterol being excreted