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Flashcards in DNA Viruses II Deck (99)
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1

HHV8 can cause a B Cell Lymphoma called

Primary Infusion Lymphoma

2

HHV8 is transmitted via the

Kissing population

3

Are particularly at risk for HHV8 infection

Elderly Russian men

4

Results in confusion with bartonella hensleae

HHV8

5

HHV8 is differentiated from Barton's with

Lymphocyte infiltrate

6

Has a neutrophil infiltrate

Bacillary angiomatosis

7

To treat HHV8, we just use

ADIS therapy

8

What is the viral classification of Polyomavirus?

Naked DS DNA virus

9

A circular DS DNA virus

Polyolyoma Virus

10

What are the two main types of polyolyoma virus?

JC (John Cunningham) virus, and BK virus

11

Causes progressive multifocal leukoencephalopathy (PML)

- Happens to immunocompromised people

Polyoma virus

12

People with AIDS are at risk for JC virus if their CD4 counts are below

200

13

A demylination disease and is multifocal

JC Virus

14

One half of people who get it die within a few months of getting it

JC disease

15

JC causes non-enhancing multifocal brain lesions in white matter. This is caused

Leukoencephalopathy

16

In JC infection, neurons become

Demyelinated

17

A classic presentation of JC (A polyoma) virus is

AIDS patient with motor neuropathy

18

BK virus causes

Nephropathy

19

BK virus causes hemorrhagic cystitis, which results in

Peeing red (blood)

20

Commonly affects transplanted patients with Kidney nephropathy and bone transplant

BK virus

21

A classic presentation of BK virus is a

Renal patient on immunosuppressants that has hematuria

22

What is the viral classification of the HPV virus

Naked DS DNA Virus

23

Cause Verruca Vulgaris, the cutaneous common wart

HPV 1 and HPV 4

24

Cause laryngeal Papillomatosis (recurrent respiratory papillomatosis), anal genital warts (condo Loma accumulata) (condyloma lata = syphilis)

HPV 6 and HPV 11

25

Cause anogenital carcinoma (Squamous Cell Carcinoma)

HPV 16 and 18

26

HPV 31 and 33 also cause

Anogenital Carcinoma

27

An inactivated quadrivalent vaccine against certain types of HPV

Gardasil

28

Gardasil protects against which types of HPV?

6, 11, 16, and 18

29

The most common STD

HPV

30

Able to upset the cell cycle, tumor suppress or proteins p53 and RB stop the advancement from G1 to S phase

HPV

31

HPV encodes E6 and E7 to promote the proteolysis of

p53 and RB

32

Cracks p53 like a crab cracker cracks shells

E6

33

Stops the progression of transition to G1S phase

p53

34

Attacks RB to prevent it

E7

35

The key buzz phrase that suggests cancer from HPV is

Bleeding after sex

36

To test for HPV, we sample the transformation zone to detect morphological changes. More specifically, we are looking for

Koilocytes

37

Important risk factor for HPV is immunosuppression, especially in HIV population and can result in

Anal or Penile Cancer

38

What is the viral classification of Parvovirus?

Naked SS DNA virus

39

The smallest virus

Parvovirus B19

40

Parvovirus B19 is transmitted via

Respiratory droplets

41

Causes slapped cheek disease, also known as fifths disease or erythema infectiosum

Parvo B19

42

Low grade fever that lasts a week, then becomes a lacy reticular pattern that goes down the body

5th's disease

43

In 5th disease, the Erythema starts on the

Face and then moves down

44

In adults, Parvo shows the signs and symptoms of

Joint pain, arthritis, and soreness

45

Parvo B19 leads to aplastic anemia in sickle cell patients has a

Cobweb look

46

When a baby in utero is exposed to Parvo, the consequences are severe and may lead to

Hydrops fetalis

47

Massive edema leading to fetal demise

Hydrops Fetalis

48

What is the viral classification of Adenovirus?

Naked DNA virus

49

Affects the adenoids and oropharynx

Adenovirus

50

Adenovirus is transmitted via

Respiratory droplets and fecal-oral

51

Most at risk is little children, military recruits, and public pools

Adenovirus

52

Adenovirus causes

-Red urine

Hemorrhagic Cystitis

53

What are the three major disease processes of Adenovirus?

Tonsilitis, Hemorrhagic cystitis, and viral conjunctivitis

54

Soldiers will always get a vaccine for adenovirus. The vaccine is a

Live vaccine

55

What is the viral classification of the Pox virus?

DS DNA virus

56

Comes with everything it needs inside of it, even making their own envelopes

Pox Virus

57

Replicates in the cytoplasm and brings its own RNA polymerase to produce all of the proteins it needs, including DNA pol

Pox Virus

58

Where the cirrus of the pox virus will replicate in the cytoplasm

Guarneri inclusion bodies

59

Forms intra-cytoplasmic bodies in cells they infect

Pox virus

60

Pox virus does not need to go into the

Nucleus

61

Finding on a biopsy which is diagnostic for Pox virus

Guarneri inclusion bodies

62

Has a dumbbell shaped core

Pox virus

63

The largest known DNA virus

Pox virus

64

Small Pox virus raised skin on surfaces

Variola

65

Causes symptoms similar to small pox

Cow pox

66

Characterized by flesh colored, dome shaped umbilicated lesions on trunk

Molluscum contageosum virus

67

Has sexual transmission in adults, with only a single lesion

Molluscum contageosum virus

68

If the lesion from molluscum contageosum spreads diffusely, it is due to

Immunosuppression

69

The major DNA virus from the Hepadnavirus family

Hepatitis B

70

What is the viral classification of Hep B?

Enveloped DS DNA virus

71

Replicates both inside the nucleus and outside the nucleus

Hepatitis B

72

Circular and partially double stranded DNA, and becomes fully double stranded during replication

Hepatitis B

73

Hep B goes from SS DNA to SS RNA then to DS DNA, because it contains its own

Reverse Transcriptase

74

We can see vertical transmission of Hep B when there is

Blood during childbirth

75

Only about 5-10% develops into chronic infection in adults

Hep B

76

What is the chance of development in newborns?

90-95%

77

Most common disorders w/ rash and arthritis, and poly arteritis nodosa (beads on a string appearance)

Hep B

78

What type of rash is accompanied by Hep B?

Purpuric rash

79

In Hep B, the kidneys are damaged by

Polyarteritis nodosa

80

Causes membranous, and membranoproliferative glomerulonephritis

Hep B

81

What is a characteristic enzymatic sign of Hep B infection?

Rising ALT

82

In the initial phase of HBV infection, serum ALT will be normal in

Neonates

83

In the titer, leads to ground glass appearance

Hep B surface Antigen

84

When there has not been enough time to create antibodies, we see spikey things that look like antigen hanging off of a virus. These are the

Hep B E antigen

85

The Hep B surface antigen and the E antigen are seen during the

Symptomatic phase

86

Positive in the window period

Anti-HEP B core antibody

87

Presence of the anti-HEP B antibody means

Low infectivity

88

Presence of the Anti Hep B Surface Antibody indicates

Recovery

89

This is the value that is checked for immunization, and will be the only one that is positive

Anti-Hep B antibody

90

Immunized people will not be positive for

HEP B Core or HEP B E antibodies

91

What is the long term sequellae of long term Hep B infections

Liver cancer

92

Circular RNA NEG, Enveloped needs HEP B surface antigen to cause infection

HEP D

93

To become infected with HBV, we need

HEP B Sag

94

Post infection from what has worse outcomes?

HEP D

95

There is a superinfection when Hep D is transmitted on top of existing

HEP B infection

96

How can we treat HBV?

Lamivudine and NRTIs

97

Can also be used to treat Hep B

Interferon Alpha

98

Neonates at risk for HBV should get

Ig w/ Hep B vaccine

99

What is the histological appearance of HBV?

Ground glass appearance