Flashcards in DNA Viruses II Deck (99)
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1
HHV8 can cause a B Cell Lymphoma called
Primary Infusion Lymphoma
2
HHV8 is transmitted via the
Kissing population
3
Are particularly at risk for HHV8 infection
Elderly Russian men
4
Results in confusion with bartonella hensleae
HHV8
5
HHV8 is differentiated from Barton's with
Lymphocyte infiltrate
6
Has a neutrophil infiltrate
Bacillary angiomatosis
7
To treat HHV8, we just use
ADIS therapy
8
What is the viral classification of Polyomavirus?
Naked DS DNA virus
9
A circular DS DNA virus
Polyolyoma Virus
10
What are the two main types of polyolyoma virus?
JC (John Cunningham) virus, and BK virus
11
Causes progressive multifocal leukoencephalopathy (PML)
- Happens to immunocompromised people
Polyoma virus
12
People with AIDS are at risk for JC virus if their CD4 counts are below
200
13
A demylination disease and is multifocal
JC Virus
14
One half of people who get it die within a few months of getting it
JC disease
15
JC causes non-enhancing multifocal brain lesions in white matter. This is caused
Leukoencephalopathy
16
In JC infection, neurons become
Demyelinated
17
A classic presentation of JC (A polyoma) virus is
AIDS patient with motor neuropathy
18
BK virus causes
Nephropathy
19
BK virus causes hemorrhagic cystitis, which results in
Peeing red (blood)
20
Commonly affects transplanted patients with Kidney nephropathy and bone transplant
BK virus
21
A classic presentation of BK virus is a
Renal patient on immunosuppressants that has hematuria
22
What is the viral classification of the HPV virus
Naked DS DNA Virus
23
Cause Verruca Vulgaris, the cutaneous common wart
HPV 1 and HPV 4
24
Cause laryngeal Papillomatosis (recurrent respiratory papillomatosis), anal genital warts (condo Loma accumulata) (condyloma lata = syphilis)
HPV 6 and HPV 11
25
Cause anogenital carcinoma (Squamous Cell Carcinoma)
HPV 16 and 18
26
HPV 31 and 33 also cause
Anogenital Carcinoma
27
An inactivated quadrivalent vaccine against certain types of HPV
Gardasil
28
Gardasil protects against which types of HPV?
6, 11, 16, and 18
29
The most common STD
HPV
30
Able to upset the cell cycle, tumor suppress or proteins p53 and RB stop the advancement from G1 to S phase
HPV
31
HPV encodes E6 and E7 to promote the proteolysis of
p53 and RB
32
Cracks p53 like a crab cracker cracks shells
E6
33
Stops the progression of transition to G1S phase
p53
34
Attacks RB to prevent it
E7
35
The key buzz phrase that suggests cancer from HPV is
Bleeding after sex
36
To test for HPV, we sample the transformation zone to detect morphological changes. More specifically, we are looking for
Koilocytes
37
Important risk factor for HPV is immunosuppression, especially in HIV population and can result in
Anal or Penile Cancer
38
What is the viral classification of Parvovirus?
Naked SS DNA virus
39
The smallest virus
Parvovirus B19
40
Parvovirus B19 is transmitted via
Respiratory droplets
41
Causes slapped cheek disease, also known as fifths disease or erythema infectiosum
Parvo B19
42
Low grade fever that lasts a week, then becomes a lacy reticular pattern that goes down the body
5th's disease
43
In 5th disease, the Erythema starts on the
Face and then moves down
44
In adults, Parvo shows the signs and symptoms of
Joint pain, arthritis, and soreness
45
Parvo B19 leads to aplastic anemia in sickle cell patients has a
Cobweb look
46
When a baby in utero is exposed to Parvo, the consequences are severe and may lead to
Hydrops fetalis
47
Massive edema leading to fetal demise
Hydrops Fetalis
48
What is the viral classification of Adenovirus?
Naked DNA virus
49
Affects the adenoids and oropharynx
Adenovirus
50
Adenovirus is transmitted via
Respiratory droplets and fecal-oral
51
Most at risk is little children, military recruits, and public pools
Adenovirus
52
Adenovirus causes
-Red urine
Hemorrhagic Cystitis
53
What are the three major disease processes of Adenovirus?
Tonsilitis, Hemorrhagic cystitis, and viral conjunctivitis
54
Soldiers will always get a vaccine for adenovirus. The vaccine is a
Live vaccine
55
What is the viral classification of the Pox virus?
DS DNA virus
56
Comes with everything it needs inside of it, even making their own envelopes
Pox Virus
57
Replicates in the cytoplasm and brings its own RNA polymerase to produce all of the proteins it needs, including DNA pol
Pox Virus
58
Where the cirrus of the pox virus will replicate in the cytoplasm
Guarneri inclusion bodies
59
Forms intra-cytoplasmic bodies in cells they infect
Pox virus
60
Pox virus does not need to go into the
Nucleus
61
Finding on a biopsy which is diagnostic for Pox virus
Guarneri inclusion bodies
62
Has a dumbbell shaped core
Pox virus
63
The largest known DNA virus
Pox virus
64
Small Pox virus raised skin on surfaces
Variola
65
Causes symptoms similar to small pox
Cow pox
66
Characterized by flesh colored, dome shaped umbilicated lesions on trunk
Molluscum contageosum virus
67
Has sexual transmission in adults, with only a single lesion
Molluscum contageosum virus
68
If the lesion from molluscum contageosum spreads diffusely, it is due to
Immunosuppression
69
The major DNA virus from the Hepadnavirus family
Hepatitis B
70
What is the viral classification of Hep B?
Enveloped DS DNA virus
71
Replicates both inside the nucleus and outside the nucleus
Hepatitis B
72
Circular and partially double stranded DNA, and becomes fully double stranded during replication
Hepatitis B
73
Hep B goes from SS DNA to SS RNA then to DS DNA, because it contains its own
Reverse Transcriptase
74
We can see vertical transmission of Hep B when there is
Blood during childbirth
75
Only about 5-10% develops into chronic infection in adults
Hep B
76
What is the chance of development in newborns?
90-95%
77
Most common disorders w/ rash and arthritis, and poly arteritis nodosa (beads on a string appearance)
Hep B
78
What type of rash is accompanied by Hep B?
Purpuric rash
79
In Hep B, the kidneys are damaged by
Polyarteritis nodosa
80
Causes membranous, and membranoproliferative glomerulonephritis
Hep B
81
What is a characteristic enzymatic sign of Hep B infection?
Rising ALT
82
In the initial phase of HBV infection, serum ALT will be normal in
Neonates
83
In the titer, leads to ground glass appearance
Hep B surface Antigen
84
When there has not been enough time to create antibodies, we see spikey things that look like antigen hanging off of a virus. These are the
Hep B E antigen
85
The Hep B surface antigen and the E antigen are seen during the
Symptomatic phase
86
Positive in the window period
Anti-HEP B core antibody
87
Presence of the anti-HEP B antibody means
Low infectivity
88
Presence of the Anti Hep B Surface Antibody indicates
Recovery
89
This is the value that is checked for immunization, and will be the only one that is positive
Anti-Hep B antibody
90
Immunized people will not be positive for
HEP B Core or HEP B E antibodies
91
What is the long term sequellae of long term Hep B infections
Liver cancer
92
Circular RNA NEG, Enveloped needs HEP B surface antigen to cause infection
HEP D
93
To become infected with HBV, we need
HEP B Sag
94
Post infection from what has worse outcomes?
HEP D
95
There is a superinfection when Hep D is transmitted on top of existing
HEP B infection
96
How can we treat HBV?
Lamivudine and NRTIs
97
Can also be used to treat Hep B
Interferon Alpha
98
Neonates at risk for HBV should get
Ig w/ Hep B vaccine
99
