Flashcards in DNA viruses- Verma Deck (216)
What are the three types of enveloped DNA viruses?
pox, herpes, hepadna
What are the four types of nake capsid DNA viruses?
What kind of virus is the human herpes virus?
enveloped DNA virus
What are the three types of alpha herpes virus?
What are the three types of beta-herpesvirus?
What are the 2 types of gamma-herpesvirus?
What happens after the primary infection of herpesvirus?
you get latent or persisten infection
When will you get reactivation of herpesvirus?
Both primary herpesvirus infection and reactivations are likely to be more serious in (blank) patients.
Herpesvirus encode their own (blank) which are targets of anti-viral drugs.
How does herpesvirus enter the cell?
How does herpesvirus replicate?
receptor mediated endocytosis
viral DNA translocates to nucleus
transcription via cellular RNA polymerase
E- enzymes for DNA rep
What is the Herpes simplex virus?
HSV-1 and HSV-2
HSV-1 and HSV-2 show latency in (blank)
neurons (latency associated with transcripts)
How do you know someone has herpes simplex virus 1 versus herpes simplex virus 2?
antigenicity and location of lesions
In HSV-1 where will you see lesions?
mouth, eye, skin (above the waist) CNS (encephalitis), disseminate to viscera in immunocompromised people
IN HSV-2 where will you see lesions?
vesicular lesions below the waist (especially genitals), CNS (meningitis), neonates and doesnt disseminate to viscera in immunocompromised people
What diseases are associated with HSV-1?
herpes labialis (cold sores)
Who primarily gets gingivostomatitis?
What are the symptoms of gingivostomatitis?
fever, irritabiity, and vesciular lesions in the mouth. THe primary disease is more severe than the recurrences
What is characteristic of herpes labialis (cold sores)?
reucrrent form-characterized by the crops of vesices at the mucocutaneous junctions of the lips or nose
What is characteristic of encephalitis?
necrotic lesion in the temporal lobe. Fever, headache and seizures
What are the 2 types of HSV-2 diseases?
What is characteristic of genital herpes?
painful vesicular lesions on the genitals.
lesions are more severe in primary disease than in recurrences
primary infection present with fever
asymptomatic infections (some people have antibody to HSV-2 but have no history of disease)
What is charachteristic of neonatal herpes?
contact with vesicular lesions within the birth cana
varies from severe disease (encephalitis) to milder local lesions (skin, eye, mouth) to asymptomatic infection
How is HSV-1 transmitted?
Where do symptoms show?
How is HSV-2 transmitted?
Where do symptoms show?
How can you get HSV-2 in the oral region and HSV-1 on the genitals?
oral-genital sexual practices
(blank) percent of people in the US are infected with HSV-1 and (bank) percent have recurrent herpes labialis