Survery of Medical Virology- Aucoin (+ strand RNA viruses) Flashcards Preview

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Flashcards in Survery of Medical Virology- Aucoin (+ strand RNA viruses) Deck (95)
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1

What are the three encapsulated +RNA viruses?

Toga
Flavi
Corona

2

What kind of virus is the rubella virus?

togavirus-rubivirus-rubella virus

3

How is rubella virus transmitted?

via respiratry droplets and mother to fetus transplacentally

4

CDC declared rubella eliminated from US in 2005, but it remains enemic in developing countries and is called (blank)

german measles

5

Where is the initial replication taking place in rubella virus?
Where does it spread to and how?

nasopharynx and local lymph nodes, spreads via blood to internal organs and skin

6

How does rubella present itself in children?

usually mild, symptoms including rash, low fever (<39 degree celcius) nausea and mild conjuctivitis

7

Congenital rubella syndrome causes significant (blank)

malformations (infection during pregnancy)

8

How do you diagnose Rubella virus?

detection of IgM or 4-fold rise in IgG titers

9

How do you protect yourself against Rubella and how long are you protected?

live attenuatd vaccine is protective for at least 10 years

10

A pregnant 16-year-old female living in Haiti is brought to the hospital in labor. The mother had a flu-like illness with a low-grade fever, maculopapular rash, and lymphadenopathy during the second month of pregnancy. On examination the baby has a blueberry muffin rash and cataracts.
What is this?

togavirus-rubivirus- rubella virus

11

(blank) are viruses that are transmitted by arthropod vectors.

Arbovirus

12

The word arbovirus is an acronym for what?

ARthropod-BOrne virus

13

What is a common vector for for arboviruses?

mosquitoes

14

What are the common clinical features of an arbovirus?

fever, headache, malaise...encephalitis and hemorrhagic fever may occur

15

What are the three arboviruses?

togaviruses
flaviviruses
bunyaviruses

16

What type of virus is Eastern equine encephaitis virus?

Togavirus-alphavirus-eastern equine encephalitis virus (EEE)

17

What kind of virus is EEE?

an arbovirus

18

How is EEE spread?

mosquitos transfer virus from wild birds (reservoir) to humans

19

What is the mortality rate of EEE?

33% mortality rate
(0-4 cases per year, outbreaks can occur)

20

EEE is prevalent in what population in the US?

in horses (i.e it is epizootic)

21

What are the symptoms of EEE?

severe headaches, nausea, vomiting, fever; changes in mental status, seizures and coma occurs

22

If you survive an EEE infection what will you be left with?

brain damage

23

How do you diagnose EEE?

isolating virus or detecting rise in antibody titer

24

Is there a way to prevent or treat EEE?

no (unless your a horse)

25

A 55-year-old man living on the Eastern Shore of Georgia is brought to the local health department clinic in August with a high fever, stiff neck, severe headache, and lethargy. Interestingly, there have been a number of deaths in horses from encephalitis in the region
What is this?

togavirus-alphavirus-EEE

26

What kind of virus is western equine encephalitis virus?

togavirus-alphavirus-WEE

27

WEE is an arbovirus T or F?

T

28

Where do you primarily see WEE?

west of mississippi and south america

29

How is WEE spread?

mosquitos transfer virus from wild birds (reservoir) to humans

30

What is the mortality rate of WEE

2%, 5-20 cases per year