Survey of medical Virology (+/- RNA) and (+ RNA via DNA) Flashcards Preview

Block 6 Week 4 > Survey of medical Virology (+/- RNA) and (+ RNA via DNA) > Flashcards

Flashcards in Survey of medical Virology (+/- RNA) and (+ RNA via DNA) Deck (34)
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1

What is the only kind of +/- RNA virus?

double capsid Reo

2

What is REO an acronym for?

respiratory enteric orphan

3

What kind of virus is a rotavirus?

Reovirus Rotavirus

4

Rotavirus has a (blank) genome

segmented, double stranded RNA genome

5

How do you transmit the rotavirus?

fecal-oral route

6

What does rotavirus cause when transmitted by fecal-oral route?

gastroenteritis

7

What is the most common cause of severe diarrhea in infants and young children?

Rotavirus

8

WHere does the rotavirus replicate?

in the mucosal cells of the small intestine

9

How does rotavirus present?

characterized by nausea ,vomiting and watery, non bloody diarrhea, low grade fever, common in children

10

How do you diagnose rotavirus?

via clinical symptoms (may use ELISA on stool samples)

11

How should you treat rotavirus?

oral rehydration therapy to replace fluids and electrolytes

12

Is there a vaccine for rotavirus?

yes 2
rotarix and rota teq

13

Since dsRNA contain a + strand, it cannot be translated as part of a duplex. So what must happen?

the (-) strand of the genomic dsRNA is first copied into mRNAs by a viral RNA-depenent RNA polymerase to produc viral proteins. Newly synthesized mRNAs are encapsulated and then copied to produce dsRNAs

14

A 10-month-year-old infant is admitted to the pediatric unit with a 2-day history of fever, vomiting, and watery, non-bloody diarrhea. Physical examination reveals a mildly dehydrated infant with a temperature of 100.4oF but who is otherwise normal. A 3-year-old sister attends a daycare center and had a mild episode of diarrhea a week ago.

What is this?

Reovirus-rotavirus

15

What is the only type of +RNA via DNA virus?

encapsulated Retro

16

What kind of virus is human T-lymphocyte virus?

retroviradea

17

HTLV is a (blank) , associated with adult T-cell leukemia (ATL)

oncovirus

18

How is HTLV spread?

by infected lymphocytes (CD4+ T cells)

19

Where will the infected T cells of HTLV be found?

in semen, blood, and breast milk

20

What is the incubation period of ATL?

long incubation period (20-50 years)

21

What are some clinical presentations of HTLV?

increased skin lesions, leukemia cells, hepatosplenomegaly, and hypercalcemia

22

How do you diagnose HTLV?

ELISA for antibody (serology)

23

Is there a vaccine or therapy for HTLV?

no

24

A 60-year-old immigrant for the Caribbean Islands was seen by a physician with complaints of persistent skin rash, fatigue, swollen glands in the groin and under arms and a distended abdomen. Physical exam revealed an enlarged liver and spleen and extensive skin rashes. Laboratory finding demonstrated a marked lymphocytosis with pleiotropic features, elevated LDH and hypercalcemia
What is this?

Retroviradae Human T lymphotropic virus

25

What kind of virus is human immunodeficiency virus?

retroviradae

26

How does HIV work?

its gp120 bind CD4 receptor on T cells, monocytes, and dendritic cells to kill them.

27

How is HIV transmitted?

sexual contact, blood, IV drug use and vertically

28

What is common in HIV?

opportunistic microbial infections

29

What does HIV present as?

acute phase- "flu like" symptoms followed by clinical latency period of weight loss, night sweats, fatigue, and lymphadenopathy

30

HOw long does it take HIV to turn into AIDS?

about 10 years

31

What is AIDS?

CD4+ T ell count of 200 cells/ml (normal 800-1200 cells/ml)

32

How do you diagnose AIDS?

serology and RT PCR to quantitate viral load

33

How do you treat AIDS?

HAART
High active anti-retroiral therapy; no vaccine

34

A 40-year-old male was seen by his internist with chief complaints of fever, night sweats, increased episodes of diarrhea during the past month, and a 30 pound weight loss over the previous 4 months. On physical exam, he had oral thrush, and cervical lymphadenopathy. Laboratory findings were significant for a CD4+ cell count of 30 cells /mL.

Retroviradae – Human immunodeficiency virus and AIDS