Flashcards in Survey of medical virology (-) strand RNA viruses Deck (141)
What is the pro name for rabies virus?
With negative sense RNA viruses, what must be included in the virion?
RNA-dependent RNA polymerase
What is essential for the replication of RNA viruses in cytoplasma?
Viral encoded RNA-dependent RNA polymerase
What kind of virus is the rabies virus?
rhabdoviridae- lyssavirus- rabies virus
What is the ONLY medically important rhabdovirus?
What kind of range does rabies have?
broad host range, infects all mammals
How is rabies transmitted?
by the bite of a rabid animal (bats, raccoons, skunks)
How many cases of rabies are in the US?
less than 10 cases/yr
What is the incubation period of rabies?
2 weeks to year
What are the 2 phases of rabies infection?
What are the symptoms of the prodrome phase of rabies?
fever, nausea, headache, spread to CNS from muscle
What are the symptoms of the neurologica phase?
hydrophobia, anxiety, paralysis, coma, death (~100%)
If you have been bitten by a rabid animal what shoud you do?
get vaccine and human rabies IgG
How do you diagnose rabies?
cytologic detection of inclusion bodies (Negri bodies) or immunochemical detection of viral antigen in brain tissue
a 20-year-old man is brought to the emergency department by his roommate because of numbness in his hand and arm, irritability, combativeness, and episodes of hyperactivity during the past week. He refuses to drink any liquids. He was bitten on the hand by a bat while trying to chase it out of his apartment about a month ago but didn’t seek medical attention. What is this?
What kind of virus is Ebola and Marburg virus?
What does eboa and marburg virus cause and what is the mortality rate?
greater than 90% mortality
What is the likely reservoir for Ebola and Marburg virus?
How is ebola and marburg virus transmitted?
by direct contact with contaminated body fluids
What does ebola and marburg virus infect?
infects macrophages and spreads via blood
Ebola and Marburg cause tissue destruction due to release of (blank) causing what?
vascular permeability, hemorrhage and shock
What are the clinical symptoms of Eboa and Marburg virus?
severe hemorrhagic fever
eventual bleeding into skin, mucous membranes, and visceral organs
Death by multiorgan failure and shock
Is there a specific treatment or vaccine against ebola and marburg virus?
How do you diagnose ebola and marburg virus?
immunoassay, PCR, serology
What are the symptoms of severe hemorrhagic fever?
joint and muscle pain
A 55-year-old male native of Sudan is brought to Yambio Hospital with sudden onset of fever, muscle pain, and headache followed by intense weakness, vomiting and diarrhea. The patient was admitted to an isolation ward where his condition deteriorated with hemorrhage into the skin, mucous membranes, and internal organs. He died 12 hours later.
What is this?
Filovirus- Ebola and Marburg virus
What kind of virus is the influenza virus?
How does the influenza virus replicate?
1 receptor mediated endocytosis
2. segmented ribonucleoproteins released into the cytoplasm
3. genoma transported to the nucleus
4. replication and transcription
5. viral mRNAs transported to the cytoplasm for translation
6. early viral replication proteins transported back to the nucleus
7. assembly and budding occurs at the PM
(blank) sickens and kills thousands/year; may cause pandemics