Drug Reactions Flashcards Preview

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Flashcards in Drug Reactions Deck (31):
1

Long QT / torsades

Sotalol, quinidine, macrolides, haldol and risperdal, TCAs

2

Hyperglycemia

Tacrolimus, protease inhibitors, niacin, HCTZ, B blockers, steroids

3

Hypothyroidism

Lithium, amiodarone, sulfonamides

4

Diarrhea

Metformin, erythromycin, colchicine, acarbose

5

Hepatic necrosis

Halothane, valproic acid, Tylenol

6

Hepatitis

Isoniazid

7

Pancreatitis

Didanosine, steroids, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

8

Agranulocytosis

Dapsone, clozapine, carbamazepine, colchicine, methimazole, PTU

9

Aplastic anemia

Carbamazepine, methimazole, PTU, NSAIDs, benzene, chloramphenicol

10

Hemolytic anemia (direct Coombs +)

Methyldopa, penicillin

11

G6PD hemolysis

Isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

12

Megaloblastic anemia

Phenytoin, methotrexate, sulfa drugs

13

Thrombocytopenia

Heparin, cimetidine

14

Gynecomastia

Spironolactone, digitalis, cimetidine, alcohol, ketoconazole

15

Hyperuricemia (gout)

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

16

Coronary vasospasm

Cocaine, sumatriptan, ergots

17

Gingival hyperplasia

Phenytoin, verapamil, cyclosporine, nifedipine

18

Myopathy

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

19

Photosensitivity

Sulfonamides, amiodarone, tetracyclines, 5-FU

20

SJS

Anti-epileptics, allopurinol, sulfa drugs, penicillin

21

SLE-like syndrome

Sulfas, hydralazine, INH, procainamide, phenytoin, etanercept

22

Seizures

INH, bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

23

Fanconi syndrome

Expired tetracyclines, heavy metal exposure

24

Interstitial nephritis

Methicillin, NSAIDs, furosemide

25

SIADH

Carbamazepine, cyclophosphamide, SSRIs

26

Pulmonary fibrosis

Amiodarone, bleomycin, methotrexate

27

Nephrotoxicity/ototoxicity

Aminoglycosides, vancomycin, loop diuretics, cisplatin

28

What are the sulfa drugs?

Probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfa abx, sulfasalazine, sulfonylureas

29

Cytochrome P-450 inducers

Chronic alcohol use, modafinil, St. John's wort, phenytoin, phenobarb, nevirapine, rifampin, griseofulvin, carbamazepine

30

Cytochrome P-450 inhibitors

Acute alcohol use, gemfibrozil, cipro, INH, grapefruit juice, quinidine, amiodarone, ketoconazole, macrolides, sulfonamides, cimetidine, ritonavir

31

Cytochrome P-450 substrates

Anti-epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs