Flashcards in Pharm: Antibiotics Deck (11):
Name the six antibiotics that act by inhibiting bacterial protein synthesis.
Aminoglycosides, tetracyclines, chloramphenicol, erythromycin, lindomycin, clindamycin
Which two classes of drugs interfere with bacterial DNA synthesis by blocking production of THF?
Sulfonamides (a PABA analogue) and trimethoprim (dihydrofolate reductase inhibitor)
Binds PBPs to block peptidoglycan cross-linking necessary for formation of bacterial cell wall
Ampicillin and amoxicillin
Same as penicillin but extended spectrum. Can be used for gram- rods as well as gram +/- cocci.
Same as penicillin but methicillin is beta lactamase resistant. Used to treat staph infections.
Same as penicillin. Used to treat infection with pseudomonas and gram- rods.
Same as penicillin but can be used in pts who are allergic to penicillin. Used against gram- rods. Somewhat resistant to beta lactamases.
Same as penicillin but broad spectrum. Administered with cilastatin to reduce inactivation by renal dihydropeptidase.
Same as penicillin but more resistant to beta lactamase.
Protein synthesis inhibitor. Binds the 30s subunit, inhibiting the formation of the ribosomal initiation complex. Used against gram- rods.