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Flashcards in Drug side effects Deck (15):
1

Seizures

Beta lactams (particularly carbepenems)

2

Hepatotoxicity

Rifampin, Macrolides (inhibits cytochrome p450)

3

Nephrotoxixity

Sulfonamides, Aminoglycosides, Vancomycin

4

Ototoxicity

Aminoglycosides, Vancomycin

5

QTc interval prolongation

Macrolides, fluoroquinolones

6

Anemia

Chloramphenicol, trimethoprim

7

Arthralgia

Quinupristin/dalfopristin, Fluoroquinolones

8

Disulfiram rxn w/EtOH

metronidazole, 2nd gen cephalosporins

9

superinfection

Clindamycin (C Diff!!!), fluoroquinolones (C diff, Candida), 3rd gen cephalosporins, Ampicillin

10

Side effects of linezolid:

Bone marrow suppression

+SSRI = hallucinations, tachycardia, agitation, nausea

11

Side effects of Aminoglycosides:

Tubular necrosis:

ototoxicity, nephrotoxicity (drug retained in renal cortex; reversible)

hearing loss in fetus

poor gut absorbtion, given IV (or topical, neomycin)

polar, excluded from CSF

12

Side effects of Tetracyclines:

form chelates with Ca+...

GI irritation

photosensitivity (abnormal sunburn rxn)

discoloration of teeth and inhibited bone growth in kids

13

Side effects of chloramphenicol:

TOXIC

Bone marrow depression

aplastic anemia

Grey baby syndrome (can't glucuronidate/decreased renal function)

14

Side effects of macrolides:

GI discomfort

Hepatic failure

prolonged QT interval

inhibit cyt p450

clarithromycin not safe in pregnancy

15

Side effects of quinupristin/dalfopristin:

arthralgia

myalgia

inhibits cyt p450