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Flashcards in C diff Deck (13):
1

What is the general classification of C diff?

gram +, rod (bacilli), anaerobic, spore forming

2

Two toxins associated with C diff?

Toxin A: enterotoxin

Toxin B: cytotoxin Hyaluronidase

3

What is the "gold standard" for C diff testing?

cytotoxin assay

4

other than cytotoxin assay, what is an important test for C diff?

ELISA- enzyme linked immunosorbent
-tests for both toxin A and B
-low sensitivity (60-80%)

5

What is the mechanism of action for toxin A?

(enterotoxin) activates inflammatory cascade in colon, disrupts the intercellular tight junctions causing fluid secretion, mucosal injury, edema, and inlammation

6

What is the mechanism of action for toxin B?

(cytotoxin) disrupts cytoskeleton, leading to mucosal injury and activation of inflammatory cascade

7

Occurs prior to sterilization, doesn't remove microbes but removes chemicals, radioactivity to make safe to handle

decontamination

8

destroys all living organisms, viruses, and endospores so they are no linger able to reproduce

sterilization

9

reduces organisms to a low enough level that disease is unlikely; inanimate objects (ie. bedpans) since often too toxic to use on human tissue

disinfectant

10

microbicide safe to use in human tissue

antiseptic

11

decrease number of microbes to a safe level but doesn't eliminate

sanitizer

12

procedure performed under sterile conditions

aseptic

13

Name an appropriate treatment for mild and severe C diff.

Mild- metronidazole

severe- vancomycin