Week 3 Diebel Bacterial Pathogenesis and Host Defense Flashcards Preview

Foundations > Week 3 Diebel Bacterial Pathogenesis and Host Defense > Flashcards

Flashcards in Week 3 Diebel Bacterial Pathogenesis and Host Defense Deck (16):
1

What type of toxin forms a hole in the host's cell membrane?

Cytolytic exotoxin

2

What are three types of hemolysins? Describe each type.

gama-non hemolytic
alpha-damage RBC but don't destroy
beta-very hemolytic, destroy cell

3

How do AB toxins work?

"B" toxin, binds to receptor protein

"A" toxin, released into cytoplasm causing some form of metabolic disruption

4

These toxins affect excitation signals from the CNS.

Neurotoxins

-can inhibit contraction (botulism)
or
-can inhibit relaxation (tetnus)

5

These exotoxins link to t-cells causing "runaway" massive systemic inflammatory response

superantigens

6

Whats a PAMP?

Pathogen Associated Molecular Pattern

-recognized by PRRs (innate)

7

What are complement components of the innate immune system?

serum proteins that bind to invading organisms and facilitate their phagocytosis

their overall goal is to control inflammatory response

activation is a cascade rxn

can be activated by antibodies or mannose binding lectin to the pathogen surface

8

What are interferons?

cytokines that mediate early response to viral infections by the innate immune system

Type 1: IFNa and IFNb are produced by infected cells

Type 2: IFNgama are released by T cells

9

What are PRRs?

Pattern Recognition Receptors-recognize PAMPs and trigger macrophage response to invasion

10

What are toll-like receptors?

a family of PRRs that bind PAMPs

TLR1-TLR9

11

What are APCs?

Antigen Presenting Cells

they link innate and adaptive immune systems by taking up and processing antigens so they can be recognized by t-cells

12

Definen epitope.

restricted part of antigen bound by antibodies

13

antibodies are?

immunoglubulin molecules that bind antigens with a high degree of specificity "tagging" them for destruction

14

What is the purpose of the constant or Fc region of an antibody?

binds to Fc receptors on phagocytes initiating phagocytosis of the bound antigen

15

What are the differences between active and passive immunity?

Active: the outcome of exposure to an antigen
-immune response made by infected individual
-immune memory in effect
-response can be maintained
-develops over a period of weeks

Passive: acquisition of PREFORMED immune cells or antibodies from a donor
-no exposure to antigen
-no immune memory
-not maintained
-immunity develops immediately

16

What is an enterotoxin?

exotoxin that targets the intestines