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Flashcards in Drugs Deck (93)
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1

Name 3 drugs that can be used to sedate delirious patients

Haloperidol, lorazepam, olanzapine

2

Name a hormone or small molecule drug used to treat chronic myeloid leukaemia

Imatinib

3

Name a selective oestrogen receptor modulator (SERM) used in breast cancer treatment

Tamoxifen

4

When is ovarian ablation used?

As a systemic hormone therapy in premenopausal breast cancer patients

5

Name 2 non-steroidal aromatase inhibitors used in breast cancer

Anastrozole, letrozole

6

Name a steroidal aromatase inhibitor used in breast cancer

Exemestane

7

Name an oestrogen antagonist used in breast cancer

Fulvestrant

8

Name 2 biological therapies used in breast cancer that bind to Her-2 receptors

Trastuzumab, lapatinib

9

What therapies might be used alongside an oestrogen antagonist in breast cancer?

Bisphosphonates, denosumab (binds to RANK-L to decrease survival of osteoclasts)

10

Name an intercalating chemotherapy drug the inserts into dsDNA

Doxorubicin

11

Name a drug used in immunotherapy for cancer that 'cuts the breaks' and enhances the T cell response

Iplimumab

12

What does implimumab do?

Immunotherapy for cancer. Enhances T cell response to cancer

13

What is denosumab?

A therapy that binds to RANK-L receptors in bone and decreases survival of osteoclasts. Decreases bone resorption

14

What is exemestane?

A steroidal aromatase inhibitor used in the treatment of breast cancer

15

What is anastrozole?

A non-steroidal aromatase inhibitor used in the treatment of breast cancer

16

Treatment of diabetic ketoacidosis

Resuscitation (0.9% IV saline)
Insulin (0.1units/kg/hr IV)
Potassium (20mmol/l IV)

17

What is metformin?

A biguanide oral diabetic medication that lowers glucose output from liver and increases uptake into skeletal muscle and adipocytes

18

What is the 1st line drug in type 2 diabetes?

Metformin, orally, 2-3 times per day with food

19

Name 3 sulphonylureas

Gliclazide, glipizide, glibenclamide

20

What is gliclazide?

A sulphonylurea drug for diabetes
Binds to K+ channels and closes them, Ca2+ enters and insulin leaves pancreatic cells

21

SE of sulphonylureas?

Hypoglycaemia, weight gain

22

Name a thiazolidenodione

Pioglitazone

23

What is pioglitazone?

A thiazolidenodione diabetic drug

24

Action of thiazolidenodiones?

Increased transcription of insulin sensitive genes in adipocytes, increased glucose uptake and use, increased lipogenesis

25

Name 2 DPP4-inhibitors

Sitagliptin, saxagliptin

26

What is sitagliptin?

A DPP4-inhibitor

27

Action of DPP-4 inhibitors?

Stops GLP-1 degredation, increased insulin and decreased glucagon and glucose
Glucose dependent action, weight loss

28

Name a GLP-1 analogue

Exenatide

29

What is exenatide?

A GLP-1 analogue

30

Action of GLP=1 analogues?

Increased insulin, decreased glucagon and glucose, decreased food intake