Drugs Flashcards
(24 cards)
How does aspirin work?
Antiplatelet - inhibits production of thromboxane A2
How does clopidogrel work?
Antiplatelet - inhibits ADP binding to its platelet receptor
How does enoxaparin work?
Inhibits factor Xa
Activates anti-thrombin III, which potentiates inhibition of coagulation factor Xa
How does fondaparinux work?
Inhibits factor Xa
Activates antithrombin III which potentiates inhibition of coagulation factors Xa
How does Bilvalirudin work?
Reversible direct thrombin inhibitor
How does abciximab work?
Glycoprotein IIb/IIIa receptor antagonist
How does eptifibatide work?
Glycoprotein IIb/IIIa receptor antagonist
How does tirofiban work?
Glycoprotein IIb/IIIa receptor antagonist
Activates antithrombin III which potentiates inhibition of coagulation factors Xa
Enoxaparin, fondaparinux
Amiodarone dose
300mg
Adenosine dose
6mg
Atropine dose
300 micrograms
Bosentan mechanism of action?
Endothelin receptor antagonist
What condition would you use bosentan in?
Primary pulmonary hypertension
Which beta-blocker can cause long QT?
Sotalol
Tricyclics, SSRIs (citalopram), haloperidol also
Which drugs can cause long QT?
Sotalol
Tricyclics, SSRIs (citalopram), haloperidol
Main action of amiodarone?
Blocks potassium channels
Drug treatment for native valve endocarditis?
Amoxicillin and gentamicin
Drug treatment for native valve endocarditis with severe sepsis, penicillin allergy or suspected MRSA
Vancomycin and gentamicin
Drug treatment for native valve with severe sepsis and risk factors for gram negative infection
Vancomycin and meropenem
Prosthetic valve endocarditis?
Really Good Valve
Rifampicin, gentamicin, vancomycin
Alteplase mechanism of action
Activates plasminogen to form plasmin
How do statins work?
Inhibit HMG-CoA reductase, the rate limiting enzyme in hepatic cholesterol synthesis
Which beta blockers have been shown to reduce mortality in stable heart failure?
Bisoprolol and carvedilol
