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Flashcards in Lectures Deck (31):
1

When would you use non-selective beta blockers (blocks beta 1 and 2 receptors)

In thyrotoxicosis
(e.g. propanolol)

2

Name a non-selective beta blocker

Propanolol

3

Beta blockers and heart failure

Good in the medium/long term, but can worsen in the short term

4

Name two dihydropyridine and side effect

Amlodipine, nifedipine
Ankle oedema

5

Name two rate limiting calcium antagonists

Verapamil, diltiazem

6

Which drugs are good for kidneys in diabetic nephropathy?

ACE inhibitors

7

Which drugs should you never use in pregnancy induced hypertension

ACE inhibitors

8

If you give this type of drug to people with aspirin sensitivity, it can cause asthma

Antiplatelets (e.g. aspirin, clopidogrel, ticagrelor)

9

Thrombin IIa inhibitor

Dabigatran

10

Factor Xa inhibitor

Rivaroxiban

11

Avoid these drugs in severe diabetic retinopathy and peptic ulcer

Fibrinolytics (e.g. streptokinase)

12

Which drugs would you use in hypertriglyceridaemia and low HDL cholesterol

Fibrates
(reduce TG and raise HDL i think)

13

Side effects of anti-arrhythmic drugs

Phototoxicity
Pulmonary fibrosis
Thyroid abnormalities

14

Signs of digoxin toxicity

Nausea, vomitting, yellow vision, bradycardia, heart block, ventricular arrhtyhmias

15

Non-invasive investigations of lower limb ischaemia

ABPI
Duplex ultrasound scanning

16

Invasive investigation of lower limb ischaemia

Magnetic resonance angiography
CT angiography
Catheter angiography

17

Drug used in intermittent claudication

Cilostazol

18

STAINS POSITIVELY FOR CONGO RED
EXHIBITS GREEN APPLE BIREFRINGENCE

Amyloid

19

Aschoff bodies

Rheumatic fever

20

Causative organism in prosthetic valve endocarditis

S. epidermidis

21

Non-bacterial thrombotic endocarditis is commonly associated with what type of cancers?

Mucinous adenocarcinomas

22

Libman-sacks endocarditis

Associated with Lupus:

Small sterile emboli
Often undersurfaces of the valves or on chords
Range of changes – often small asymptomatic deposits or significant valvulitis

23

What are carcinoid tumours?

Neoplasms of neuroendocrine cells

24

What is carcinoid syndrome?

Excess 5HIAA, serotonin, histamine, bradykinin etc produced by tumour - flushing of skin, nausea, vomiting, diarrhoea
PRODUCES RIGHT SIDED CARDIAC DISEASE
-tricuspid and pulmonary insufficiency

25

What is a distal vein thrombosis

A DVT in the calves

26

What is a proximal vein thrombosis

A DVT of the popliteal or femoral vein

27

How long should you give vitamin K antagonist (warfarin) therapy for an idiopathic venous thromboembolism?

3 months

28

Is there a higher recurrence of provoked or unprovoked (idiopathic) venous thromboembolism?

Higher recurrence rate in unprovoked (idiopathic) venous thromboembolism

29

What is post-thrombotic syndrome?

A relatively frequent complication of DVT:
-pain
-oedema
-hyperpigmentation
-eczema
-varicose collateral veins
-venous ulceration

30

Investigation for PE in pregnancy

Perfusion scan (basically a V/Q scan without the Q)

31

What is Fragmin?

Dalteparin (a LMWH)