drugs for lipid disorders

Question 1

what lipid accounts for 90% of the lipids in the body

Answer 1

triglycerides

Question 2

what lipids are essential for the formation of plasma membranes

Answer 2

phospholipids

Question 3

what kind of fat is cholestoral

Answer 3

steroids

Question 4

what is cholesterol an essential component for

Answer 4

it is the essential component of the plasma membrane

Question 5

what is considered the building block for bile acids, vitamin d, cortisol, estrogen, and testosterone

Answer 5

cholesterol

Question 6

what can synthesize cholestoral

Answer 6

liver

Question 7

high density lipoprotien

Answer 7

bad

Question 8

low density lipoprotien

Answer 8

good

Question 9

ldl - do what

Answer 9

transport cholesterol from the liver to tissues

Question 10

vldl is the priamry carrier for what and is coverted into what

Answer 10

this is the primary carrier of triglycerides, converted into LDL; reduced to LDL

Question 11

what is the primary carrier of triglycerides and converted into LDL

Answer 11

vldl

Question 12

hdl - does what

Answer 12

transports cholestoral from tissues back to the liver

Question 13

what is capable of reverse cholesterol transport

Answer 13

VLDL

Question 14

what occurs predominantly in men compared to non-menopausal women

Answer 14

dyslipidemia

Question 15

what does dyslipidemia increase the risk foe

Answer 15

increases the risk for atherosclerosis and coronary artery disease

Question 16

what is dyslipidemia associated with

Answer 16

associated with genetic alterations in fat metabolism and excessive dietary intake

Question 17

what is associated with genetic alterations in fat metabolism and excessive dietary intake

Answer 17

dyslipidemia

Question 18

non-pharmacological treatment (4)

Answer 18

smoking cessation
moderate alcohol consumption
maintain weight and waist circumference
regular exercise

Question 19

smoking cessation
moderate alcohol consumption
maintain weight and waist circumference
regular exercise are all non-pharmacological management strategies for

Answer 19

pipid disorders

Question 20

statins are what

Answer 20

HMG-CoA reductase inhibitors

Question 21

what is the first line therapy in treating lipid disorders

Answer 21

statins

Question 22

how do statins work

Answer 22

they inhibit activity of HMG CoA reductase, blocking cholesterol synthesis

Question 23

what increases the # of LDL receptors in the liver and stimulates the removal of LDL from the blood

Answer 23

statin

Question 24

what efficacy do statins have

Answer 24

high

Question 25

when would statins be contraindicated?

Answer 25

in women who are pregnant and women who may become

Question 26

do statins have drug drug interactions, or drug food interactions

Answer 26

drug food

Question 27

what drug food interactions do statins have

Answer 27

alcohol and grapefruit juice

Question 28

why should someone not drink alcohol or grape juice while taking statins

Answer 28

because they inhibit CYP 450 enzymes

Question 29

what does the inhibition of the cyp 450 enzymes increases the risk of what

Answer 29

risk of rhabdomyolysis

Question 30

what is the risk of rhabdomyolysis associated with

Answer 30

inhibition of cyp 450 enzymes

Question 31

when combined with oral contraceptives, what effect do statins have

Answer 31

 Statins potentiate the effects of warfarin and increase estrogen levels in women using combination oral contraceptives

Question 32

what increases the bioavailability of some statin drugs

Answer 32

proton pump inhibitors and h2ra

Question 33

selective cholesterole absorption inhibitors

Answer 33

inhibit intestinal cholestoral absorption

Question 34

what work to inhibit intestinal cholestoral absorption

Answer 34

selective cholesterol absorption inhibitors

Question 35

what is a common adverse effect of selective cholestoral inhibitors

Answer 35

gi distress

Question 36

when are selective cholestoral inhibitors co-adminsitered with statin therapy

Answer 36

when the client fails to reach their ldl levels

Question 37

what can selective cholestoral absorption inhibitors not be co-adminsitered with

Answer 37

bile acid resins

Question 38

why cant bile acid resins be co-administered with statin therapy

Answer 38

because they reduce the efficacy of the statin

Question 39

bile acid resins

Answer 39

interfere with the absorption of drugs

Question 40

if a patient has to take bile acid resins and is also taking medications that may cause drug-drug interactions, what would you advise them

Answer 40

to take other medications 1hr before or 4 hours after

Question 41

what may induce vitamin deficiency

Answer 41

bile acid resins

Question 42

what vitamin deficiency leads to increased bleeding times

Answer 42

vitamin k

Question 43

PCSK9 inhibitors

Answer 43

work to label ldl molecules for destruction

Question 44

how do PCSK9 inhibitors work

Answer 44

they inhibit pcsk9 protiens that target liver LDL receptors for degardion

Question 45

what is no longer recommended for patients with lopid disorders

Answer 45

niacin

Question 46

what has poor efficacy rt risk of major vascular events

Answer 46

niacin

Question 47

what has an unacceptable toxicity profile for most patients

Answer 47

niacin