Drugs for Mood Disorders

Question 1

They are the most common antidepressant

Answer 1

Selective Serotonin Re-uptake Inhibitors

Question 2

1st drug available in 1988 (antidepressant)

Answer 2

Fluoxetine

Question 3

Examples of SSRIs

Answer 3

Fluoxetine (Prozac)
Sertraline (Zoloft)
Citalopram (Celexa)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Fluvoxamine (Luvox, Faverin)

Question 4

Pharmacokinetics of SSRIs

Answer 4

Highly lipophilic
Good absorption after oral administration
Important biotransformation in the liver

Question 5

SSRI for Bulimia nervosa

Answer 5

Fluoxetine

Question 6

Adverse Effects of SSRIs

Answer 6

Gastrointestinal effects
Sexual effects (loss of libido)
Increase in headaches
Discontinuation syndrome
Serotonin syndrome

Question 7

A condition of too much serotonin in the body.

Answer 7

Serotonin Syndrome

Question 8

What does SNRIs lack that TCAs have

Answer 8

antihistamine
α-adrenergic blocking
anticholinergic

Question 9

What are the examples of Selective Serotonin - NE Reuptake Inhibitors (SNRI)

Answer 9

Venlafaxine
Desvenlafaxine
Duloxetine
Milnacipran

Question 10

Indications for SNRIs

Answer 10

Major depression
Pain disorders
General anxiety (GAD)
Stress urinary incontinence
Vasomotor symptoms of menopause

Question 11

SNRI treatment for Neuropathies, Fibromyalgia (Pain Disorders)

Answer 11

Milnacipran

Question 12

SNRI with history of liver damage

Answer 12

Duloxetine

Question 13

Three-ring nucleus (lipophilic nature), originally developed as antipsychotics (1949)

Answer 13

Tricyclic Antidepressants

Question 14

Examples of Tricyclic Antidepressants (TCA)

Answer 14

Imipramine (Tofranil) - prototype
Desipramine (Norpramin)
Amitryptiline
Clomipramine (Anafranil)
Nortryptiline (Pamelora)
Amoxapine
Doxepine
Dosulepine (Prothiaden)

Question 15

They have rapid absorption, extensive first pass effect = low and inconsistent BAV

Answer 15

Tricyclic Antidepressants