SNS Direct Acting

Question 1

Natural catecholamines contain the following except:

Epinephrine
Norepinephrine
Isoproterenol
Dopamine

Answer 1

Isoproterenol (Synthetic catecholamine)

Question 2

OH groups show highest potency in
activating alpha or beta receptors (T/F)

Answer 2

True

Question 3

COMP Post-Synapse can be found in the ________ while Mao (Intraneurally) can be found in the _________ and _______

Answer 3

Gut wall

Liver and Gut wall

Question 4

Poor penetration into the CNS is because of polar (T/F)

Answer 4

True

Question 5

Direct Acting Non-selective Agonists have great oral absorption (T/F)

Answer 5

False (poor absorption)

Question 6

Direct Acting Non-selective Agonists are easily degraded by _________ environment

Answer 6

Acidic (Acid Labile)

Question 7

Direct Acting, Non-selective Agonists can cause VASOCONSTRICTION which can limit their own absorption (T/F)

Answer 7

True

Question 8

What are the examples of Direct Acting, Non-selective Agonists

Answer 8

NE (Levophed)
Epi (Adrenalin)
Dopamine stimulates
Isoproterenol

Question 9

It is a potent vasoconstrictor and cardiac stimulant

Answer 9

Epinephrine (Adrenalin)

Question 10

Other tern used for Norepinephrine (Levophed)

Answer 10

Levarterenol
Noradrenaline

Question 11

It is the immediate metabolic precursor of NE

Answer 11

Dopamine

Question 12

Norepinephrine (Levophed) systematic use for

Answer 12

hypotension

Question 13

It is a potent bronchodilator, and an example of synthetic catecholamines

Answer 13

Isoproterenol (Isoprenalin)

Question 14

They are the Direct Acting, Alpha-1- Selective Agonists

Answer 14

METHOXAMINE
MIDODRINE
NASAL DECONGESTANTS