Drugs_anti HIV Flashcards Preview

T7. Pharmacology > Drugs_anti HIV > Flashcards

Flashcards in Drugs_anti HIV Deck (65):
0

Zidovudin

Antiviral drug_HIV
Neucleosides

1

Lamivudine

Antiviral drug_HIV
Nucleosides (NRTIs)

2

Zidovudine + Lamivudine (Combivir)

given after accidental needle stick

3

Efavirenz

Antiviral drug_HIV
Nonnucleosides (NNRTIs)

4

Atazanavir

Antiviral drug_HIV
Protease inhibitor prevent formation of new viral particles

5

Fosamprenavir

Antiviral drug_HIV
Protease inhibitor; prodrug of amprevavir

6

Enfuvirtide

Antiviral drug_HIV
Fusion inhibitor block the binding of HIV to CD4 lymphocytes receptors that is required for HIV to enter cells

7

Raltegravir

Antiviral drug_HIV
Integrase inhibitor prevent integration of viral DNA into the DNA of the infected cells

8

2 RT inhibitor + 1 protease inhibitor

most effective tx of HIV

9

Amantadine

Antiviral_Influenza
Influenza type A infection prevention and treatment

10

Zanamivir

Antiviral drug_Neuraminidase inhibitors
Influenza A and B infection prevention and treatment

11

Acyclovir

Antiviral_Herpes
Herpes simplex type 1 and 2 (HSV-1, HSV-2)
Varicella zoster virus (VZV)
Epstein-Barr virus (EBV), Cytomegalovirus (CMV)- mono
*TOPICAL, IV, ORALLY for herpes infections

12

Foscarnet

Antiviral_herpes
approved for CMV retinitis, acyclovir-resistant HSV and VZV infections

13

Gancyclovir

Antiviral_herpes
Drug of choice for Cytomegalovirus infections

14

Aedefovir

Antiviral_hepatic viral
Hep B virus

15

Tenofovir

Antiviral_hepatic viral
Hep B virus

16

Pegylated interferon

Antiviral_hepatic viral
Hep B virus
inhibit viral RNA translation

17

Lamivudine

Antiviral_hepatic viral
Hep B virus
inhibitor of HBV DNA polymerase and HIV reverse transcriptase

18

Pegylated interferon alpha-2a

Antiviral_hepatic viral
Hep C infection

19

Pegylated interferon alpha-2b

Antiviral_hepatic viral
Hep C infection

20

Ribavirin

Antiviral_hepatic viral
Hep C infection

21

Cyclophosphamide

Anticancer drug
Alkylating agent
Most commonly used alkylating agent

22

u/e Cyclophosphamide

hemorrhagic cystitis

23

6-mercaptopurine

Anticancer drug
Antimetabolites

24

5-flurouracil

Anticancer
Antimetabolites

25

Methotrexate

Anticancer drug
Antimetabolites
Psoriasis, severe active rheumatoid arthritis in addition to whole variety of cancers
*administered intrathecally

26

Doxorubicin

Anticancer drug
Antibiotics

27

u/e Doxorubicin

Cardiotoxicity, alopecia and bone marrow depression

28

Bleomycin

Anticancer drug
Antibiotics

29

u/e Bleomycin

fatal pulmonary fibrosis
*extreme caution- preexisting history of lung disease

30

Plicamycin

Anticancer drug
Antibiotics
tx. Life-threatening hypercalcemia associated with malignancy

31

Vincristine

Anticancer drug
Microtubule inhibitor

32

u/e Vincristine

neurologic toxicity

33

Vinblastine

Anticancer drug
Microtubule inhibitor

34

u/e Vinblastine

bone marrow toxicity

35

Anastrozole

Anticancer drug
Hormonal agent_aromatase inhibitor
tx. estrogen-dependent breast cancer resistant to tamoxifen

36

Tamoxifen

Anticancer drug_Antiestrogen
tx. estrogen receptor positive breast cancer
*competitive antagonists of estrogen receptor

37

Flutamide

Anticancer drug_androgen receptor antagonist
tx. prostate cancer

38

Leuprolide

Anticancer drug_GnRh analog
tx. metastatic prostatic cancer

39

Rituximab

Anticancer drug_monoclonal antibodies
tx. chronic lymphocytic leukemia

40

Imatinib

Anticancer drug_other
tx. chronic myeloid leukemia

41

Geftinib

Anticancer drug_other
tx. non small cell lung cancer

42

Etoposide

Anticancer drug_other
tx. small cell carcinoma of the lungs

43

Cisplatin and Cardbaplatin

Anticancer drug_other
tx. testicular carcinoma, ovarian carcinoma, bladder carcinoma

44

Procarbazine

Anticancer drug_other
tx. Hodgkin's disease

45

L-asperginase

Anticancer drug_other
tx. childhood acute lymphocytic leukemia (ALL)

46

Bacille Calmette-Guerin (BGC) vaccine

TB vaccine, effective in treating small localized superficial urinary bladder carcinoma
Intravesicular use
Non-specific stimulant of the reticuloendothelial system

47

Asprin

Anti-inflammatory drug
Non selective inhibitors of cyclooxygenase

48

u/e Asprin

Reye syndrome if given in viral infections, especially in children

49

Diclofenac

Anti inflammatory drug
Non-selective inhibitors of cyclooxygenase

50

Indomethacin

Anti inflammatory drug
Non selective inhibitors of cyclooxygenase
tx. in patent ductus arteriosus (PDA) in new born babies

51

Celocoxib (Celebrax)

Anti inflammatory drug_selective COX-2 inhibitor
lower risk for GI bleeding, good for chronic use

52

u/e Celocoxib (Celebrex)

hypertention

53

Rofecoxib (Vioxx)

Anti inflammatory drug_selective COX-2 inhibitor
Withdrawn?

54

Acetaminophen

Anti inflammatory drug_analgesics
antipyretic, analgesic; weak anti inflammatory activity

55

Infliximab

Anti inflammatory drug_arthritis
Crohn's disease

56

Methotrexate

Anti inflammatory drug_disease-modifying anti-rheumatic drug

57

D-Penicillamine

Anti inflammatory drug_disease-modifying anti-rheumatic drug
also tx. heavy metal poisoning, Wilson's disease

58

Aliopurinol

Gout
reduce uric acid formation

59

Colchicine

Gout drug
tx. acute attack of gout

60

Probenecid

Gout drug
uricosuric drug- increase uric acid excretion by the KD

61

Cyclosprorine (CsA)

Immunosuppressive drug_selective inhibitors of cytokine production and fx
Prevention and treatment of transplanted organ rejections

62

u/e Cyclosprorine (CsA)

nephrotoxicity, thromboembolism, neurotoxicity, seizure etc.

63

Azathioprine

Immunosuppressive drug_immunosuppressive antimetabolites
t-cells and b-cells are particularly affected by the inhibition of purine synthesis

64

Mycophenolate mofetil

Immunosuppressive drug_immunosuppressive antimetabolites
inhibits an enzyme that helps the growth of Tcells and Bcells