Flashcards in W7 : Thyroid Disorder Drugs Deck (10):
sx of Hypothyroidism
slow heart rate, cold intolerance, physical slowing, (in children), hypothyroidisim can result in mental retardation and short stature.
sx. of Hyperthyroidism
fast HT rate, nervousness, tremor and excess heat production
what is Levothyroxine (T4)(Synthroid)?
drug of choice for hypothyroidism
what is MOA_Levothyroxine?
It replaces normal serum levels of T4 and T3.
*T4 is converted to T3 in the periphery.
drugs to treat hyperthyroidism?
What is MOA_Methimazole (Tapazole)?
Inhibits iodination of tyrosine groups and coupling of these groups to form thyroid hormone.
What is MOA_Propylthiouracil (PTU)?
Inhibits peripheral conversion of T4 to T3.
What is MOA_Iodine/Iodide?
Inhibits release of thyroxine from thyroid gland.
Useful for 2 weeks then the gland adapts and resumes thyroxine secretion.
What is MOA_Propranolol (Inderal)?
B- Blocker that suppresses tachycardia and other catecholamine effects.