W7 : Thyroid Disorder Drugs Flashcards Preview

T7. Pharmacology > W7 : Thyroid Disorder Drugs > Flashcards

Flashcards in W7 : Thyroid Disorder Drugs Deck (10):
0

sx of Hypothyroidism

slow heart rate, cold intolerance, physical slowing, (in children), hypothyroidisim can result in mental retardation and short stature.

1

sx. of Hyperthyroidism

fast HT rate, nervousness, tremor and excess heat production

2

what is Levothyroxine (T4)(Synthroid)?

drug of choice for hypothyroidism

3

what is MOA_Levothyroxine?

It replaces normal serum levels of T4 and T3.
*T4 is converted to T3 in the periphery.

4

drugs to treat hyperthyroidism?

Methimazole (Tapazole)
Propylthiouracil (PTU)
Iodine/Iodide
Propranolol

5

What is MOA_Methimazole (Tapazole)?

Inhibits iodination of tyrosine groups and coupling of these groups to form thyroid hormone.

6

What is MOA_Propylthiouracil (PTU)?

Inhibits peripheral conversion of T4 to T3.

7

What is MOA_Iodine/Iodide?

Inhibits release of thyroxine from thyroid gland.
Useful for 2 weeks then the gland adapts and resumes thyroxine secretion.

8

What is MOA_Propranolol (Inderal)?

B- Blocker that suppresses tachycardia and other catecholamine effects.

9

What is the use of B-Blocker, Propranolol in managing hyperthyroid patients?

Used for emergent preparation of hyperthyroid patients for surgery, thyrotoxicosis in pregnancy and thyroid storm.