W7 : Antihyperlipidemic Drugs Flashcards Preview

T7. Pharmacology > W7 : Antihyperlipidemic Drugs > Flashcards

Flashcards in W7 : Antihyperlipidemic Drugs Deck (12):
0

What are classes of Antihyperlipidemic drugs?

1. HMG-CoA reductase inhibitors
2. Fibrates
3. Niacin (Nicobid)
4. Bile acid sequestrants
5. Cholesterol absorption inhibitors

1

What are the drugs of first choice for the treatment of hypercholesterolemia?

HMH-CoA reductase inhibitors

2

What is Simvastatin (Zocor)?

HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

3

What is Atrovastatin (Lipitor)?

Most potent HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

4

What is Rosuvastatin (Cerstor)?

Most potent HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

5

What are adverse effects of HMG-CoA reductase?

LV Fx abnormalities, myopathy, rhadbomyolysis (disintegration of muscle), etc.
*NO GRAPEFRUIT JUICE

6

What is MOA_HMG-CoA reductase?

Inhibit HMG-CoA reductase, which controls the rate-limiting step in cholesterol synthesis

7

What is MOA_Niacin?

Strongly inhibits lipolysis in adipose tissue--> decrease cholesterol, TG, LDL, VLDL and increases HDL

8

What is adverse effects of Niacin?

Flush and pruritus

9

What is MOA_bile acid sequestrants?

Bind bild acids in the SI, prevent their reabsorption
--> LV use cholesterol to make more bile acids
--> decrease cholesterol and LDL, increase TG and HDL

10

What is Cholestyramine (Questran)?

Bile acid sequestrant

11

What is MOA_Ezetimibe?

Inhibit intestinal absorption of dietary and biliary cholesterol
--> decrease of LDL & TG, increase HDL