Flashcards in ECM Deck (120)
Connective tissue has a high ratio of ___ to cells in connective tissue.
What function does the ECM play in connective tissue?
Structural - provides architectural framework
What determines the physical properties of the connective tissue?
Composition of the matrix
The ECM provides support for what?
Cells and cell layers
The ECM acts as a barrier to what?
The ECM acts as a passive-selective ___-___ between tissue compartments.
What acts as a solid phase regulator of cell attachment, growth and differentiation?
ECM modulates what process?
What are the three structural components of ECM?
Amorphous ground substance
What is a filament?
A threadlike structure (2-20 nm dia.)
Typically a single molecule or linear chain of molecules
Microfibrils are an aggregate of what?
What is the typical diameter of a microfibril?
45-100 nm diameter
What is an aggregate of microfibrils called?
What is the diameter of a fibril?
200-500 nm diameter
What is an aggregate of fibrils called?
How big are fibers?
1-20 micrometers in diameter
What are the two types of fibers in the ECM?
How big are bundles?
20-100 micrometers in diameter
What makes up ground substance?
A complex mixture of glycoproteins, gags and proteoglycans
Ground substance helps bind cells to what of connective tissues?
Ground substance fills the space between what?
Cells and fibers in connective tissue
What is a glycoprotein?
A protein with one or more attached sugars
A GAG is a family of what?
GAGs are very ___ and very ___ ___.
What is a proteoglycan composed of?
Protein core with many GAG chains attached
What glycoproteins are found in interstitial connective tissue?
What glycoproteins are found in basement membranes?
What are the small leucine-rich proteoglycans?
What are the modular proteoglycans involved in nonhyaluronan binding?