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Flashcards in ECM Deck (120)
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1

Connective tissue has a high ratio of ___ to cells in connective tissue.

ECM

2

What function does the ECM play in connective tissue?

Structural - provides architectural framework

3

What determines the physical properties of the connective tissue?

Composition of the matrix

4

The ECM provides support for what?

Cells and cell layers

5

The ECM acts as a barrier to what?

Cells

6

The ECM acts as a passive-selective ___-___ between tissue compartments.

Molecular sieve

7

What acts as a solid phase regulator of cell attachment, growth and differentiation?

ECM

8

ECM modulates what process?

Mineralization process

9

What are the three structural components of ECM?

Fibers
Amorphous ground substance
Basement membrane

10

What is a filament?

A threadlike structure (2-20 nm dia.)
Typically a single molecule or linear chain of molecules

11

Microfibrils are an aggregate of what?

Filaments

12

What is the typical diameter of a microfibril?

45-100 nm diameter

13

What is an aggregate of microfibrils called?

A fibril

14

What is the diameter of a fibril?

200-500 nm diameter

15

What is an aggregate of fibrils called?

A fiber

16

How big are fibers?

1-20 micrometers in diameter

17

What are the two types of fibers in the ECM?

Collagen
Elastic

18

How big are bundles?

20-100 micrometers in diameter

19

What makes up ground substance?

A complex mixture of glycoproteins, gags and proteoglycans

20

Ground substance helps bind cells to what of connective tissues?

Fibers

21

Ground substance fills the space between what?

Cells and fibers in connective tissue

22

What is a glycoprotein?

A protein with one or more attached sugars

23

A GAG is a family of what?

Heteropolysaccharides

24

GAGs are very ___ and very ___ ___.

Hydrated
Negatively charged

25

What is a proteoglycan composed of?

Protein core with many GAG chains attached

26

What glycoproteins are found in interstitial connective tissue?

Fibroconectins
Elastin
Fibrilins
Tenascins
Thrombospondins
Microfibril-associated matrilins

27

What glycoproteins are found in basement membranes?

Laminins
Nidogen/entactin
Fibulin

28

What are the small leucine-rich proteoglycans?

Decorin
Biglycan
Fibromodulin
Lumican
Epiphycan

29

What are the modular proteoglycans involved in nonhyaluronan binding?

Prelecan
Agrin
Testican

30

What modular proteoglycans are involved in hyaluronan and lectin binding?

Aggrecan
Versican
Neurocan
Brevican