Ectopic Pregnancy Flashcards
(13 cards)
What are the management options for ectopic pregnancy?
Methotrexate and surgery
What is an ectopic pregnancy?
Pregnancy implanted outside of the uterus which needs to be removed.
What is the laprascopic treatment of pregnancy?
In the 1920’s - 1977 this was removal of the affected tube.
Tubul aspiration or salpingotomy discovered in the 1980’s
Why do we need more ectopic pregnancy treatment options above methotrexate?
Methotraxate fails in 30% of pregnancy
Its slow to work
Expensive
What was the progesterone receptor antagonist study in 2008?
Methotrexate and mifepristone leading to 13% more resolved pregnancies that methotrexate alone.
What was the GnRH antagonist study?
GnRH promotes proliferation, migration, invasion and inhibits apoptosis. It also stimulates HCG which is all bad for ectopic pregnancy and therefore stopping this may resolve pregnancy quicker.
What was the mouse GnRH receptor study?
Caused pregnancy then used a GnRHR agonist which induced complete pregnancy loss
What was the results of the rat mifepristone and letrovozole study?
Used mifepristone and letrozole which induced almost 100% pregnancy loss in rats,
only 50% pregnancy loss in letrozole in baboons
Why is it hard to research ectopic pregnancies in animal models?
Tubul implantation doesn’t really happen in other types of animals
What was the Gefitinab mouse model?
They caused an ectopic pregnancy by placing trophoblast tumour cells in the fallopian tubes.
When gefitinab and methotrexate was administered they found tumour volume decreased
Gefitinab and methotrexate melbourne trial? (Gem1)
Found these drugs worked, all women got their period back, it reduced hospital visits.
What happened in the Gem2 trial?
70% of pregnancies lost
What happened in the Gem3?
Double blind trial which saw no real difference between methotrexate and gefitinab and the placebo group.
