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Flashcards in ED Drugs Deck (21)
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1

Alprostadil MOA

Synthetic PGE1; stimulates AC/cAMP/PKA pathway to decrease intracellular Ca2+ resulting in smooth muscle relaxation thus ERECTION

2

Alprostadil Tox

Local action-avoids systemic effects; MC=penile, urethral, or testicular pain; rarely CV AE's

3

Alprostadil PK

Rapid onset (mins); Effects lasts up to several hours

4

Alprostadil Admin

Administrations: Urethral Suppository vs. Intra-cavernosal Injection

5

PDE-5 Inhibitors

Avanafil, Sildenafil Tadalafil, Vardenafil

6

Avanafil Tox

h/a; NAION, sudden hearing loss, unstable angina

7

Avanafil DME

3A4>>2C; fecal/renal elim; .5-.75 hr onset, 5 hr half-life

8

Sildenafil Tox

h/a, indigestion, visual disturbances, epistaxis; NAION, sudden hearing loss

9

Sildenafil DME

3A4>>2C; fecal/renal elim; >1 hr onset, 4 hr half-life

10

Tadalafil Tox

h/a, indigestion, nausea, backache, myalgia, flushing, RTIs, nasopharyngitis; NAION, sudden hearing loss, angina, MI, tachycardia

11

Tadalafil DME

3A4; fecal/renal elim; 2-4 hr onset, <35 hr half-life

12

Vardenafil Tox

h/a, flushing, rhinitis; NAION, sudden hearing loss, angina, MI
UNIQUE = heart stuff

13

Vardenafil DME

3A4 & 2C; fecal/renal elim; 1 hr onset & dec by high fat meal, 5 hr half-life

14

Vardenafil DDI

NITRATES;
DDI's with >70 drugs that inc risk of QT prolongation/arrhythmias

15

Testosterone use in ED

May improve response of hypogonadal men to PDE-5 inhibitors

16

Yohimbine MOA

Inc relaxation of penile smooth muscle in 2 ways; 1. alpha-2 receptor inhibitor
2. antagonizes presynaptic inhibition of NANC nerves to inc release of NO

17

Yohimbine Tox

Crosses BBB easily: anxiety, antidiuresis, dizziness, flushing, h/a, HTN, inc motor activity, irritability, nervousness/restlessness, sinus tachycardia, tremor; Worsens renal fxn in failure/dysfxn=CI

18

Yohimbine PK

Rapid (variable) absorption; complete rapid metabolism; 30 min half-life

19

Yohimbine DDI

MAOI action at supra-clinical doses: tyramine & caffeine interactions possible

20

PDE-5 inhibitor also used for BPH

Tadalafil (35 hour half life)

21

Yohimbine CI

renal failure/dsyfxn