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ED Drugs Flashcards

(21 cards)

1
Q

Alprostadil MOA

A

Synthetic PGE1; stimulates AC/cAMP/PKA pathway to decrease intracellular Ca2+ resulting in smooth muscle relaxation thus ERECTION

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2
Q

Alprostadil Tox

A

Local action-avoids systemic effects; MC=penile, urethral, or testicular pain; rarely CV AE’s

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3
Q

Alprostadil PK

A

Rapid onset (mins); Effects lasts up to several hours

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4
Q

Alprostadil Admin

A

Administrations: Urethral Suppository vs. Intra-cavernosal Injection

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5
Q

PDE-5 Inhibitors

A

Avanafil, Sildenafil Tadalafil, Vardenafil

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6
Q

Avanafil Tox

A

h/a; NAION, sudden hearing loss, unstable angina

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7
Q

Avanafil DME

A

3A4»2C; fecal/renal elim; .5-.75 hr onset, 5 hr half-life

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8
Q

Sildenafil Tox

A

h/a, indigestion, visual disturbances, epistaxis; NAION, sudden hearing loss

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9
Q

Sildenafil DME

A

3A4»2C; fecal/renal elim; >1 hr onset, 4 hr half-life

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10
Q

Tadalafil Tox

A

h/a, indigestion, nausea, backache, myalgia, flushing, RTIs, nasopharyngitis; NAION, sudden hearing loss, angina, MI, tachycardia

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11
Q

Tadalafil DME

A

3A4; fecal/renal elim; 2-4 hr onset, <35 hr half-life

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12
Q

Vardenafil Tox

A

h/a, flushing, rhinitis; NAION, sudden hearing loss, angina, MI
UNIQUE = heart stuff

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13
Q

Vardenafil DME

A

3A4 & 2C; fecal/renal elim; 1 hr onset & dec by high fat meal, 5 hr half-life

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14
Q

Vardenafil DDI

A

NITRATES;

DDI’s with >70 drugs that inc risk of QT prolongation/arrhythmias

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15
Q

Testosterone use in ED

A

May improve response of hypogonadal men to PDE-5 inhibitors

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16
Q

Yohimbine MOA

A

Inc relaxation of penile smooth muscle in 2 ways; 1. alpha-2 receptor inhibitor
2. antagonizes presynaptic inhibition of NANC nerves to inc release of NO

17
Q

Yohimbine Tox

A

Crosses BBB easily: anxiety, antidiuresis, dizziness, flushing, h/a, HTN, inc motor activity, irritability, nervousness/restlessness, sinus tachycardia, tremor; Worsens renal fxn in failure/dysfxn=CI

18
Q

Yohimbine PK

A

Rapid (variable) absorption; complete rapid metabolism; 30 min half-life

19
Q

Yohimbine DDI

A

MAOI action at supra-clinical doses: tyramine & caffeine interactions possible

20
Q

PDE-5 inhibitor also used for BPH

A

Tadalafil (35 hour half life)

21
Q

Yohimbine CI

A

renal failure/dsyfxn