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Flashcards in Prostate Drugs Deck (40)
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1

Alfuzosin MOA

Short-acting selective Alpha-1 Blocker

2

Alfuozosin Tox

GI-xerostomia, nausea; CNS- dizziness, somnolence, asthenia, h/a, insomnia

3

Alfuozosin M&E

CYP3A4; fecal/renal elim

4

Does alfuozosin need does titration?

No

5

Tadalafil MOA

PDE-5 Inhibitor: decreases breakdown of cGMP; Relief of BPH occurs via smooth muscle relaxation

6

Tadalafil Tox

Uncommon; h/a, nausea, indigestion, nasopharyngitis, URTI; more rare-NAION, retinal artery occlusion, hearing loss

7

Tadalafil M&E

CYP3A4; fecal elim

8

Tadalafil DDI

Nitrates-profound hypotension exacerbated by alcohol

9

Saw Palmetto?

useless shit drug

10

Androgen Receptor Blockers (3)

Bicalutamide, flutamide, nilutamide

11

Bicalutamide MOA

Androgen Receptor Blocker; Prostate > Central; Antagonist + some agonist activity

12

Bicalutamide Tox

GI tox, hot flashes, aches/pains

13

Flutamide MOA

Androgen Receptor Blocker; Prostate; Antagonist

14

Flutamide Tox

GI tox, hot flashes, aches/pains
AND
Blood Dyscrasia

15

Flutamide BBW

Hepatotoxicity/Failure

16

Nilutamide MOA

Androgen Receptor Blocker; prostate & central

17

Nilutamide Tox

GI tox, hot flashes, aches/pains
AND
HF/ HTN, Blood Dyscrasia; Increased time to accommodate transition from light to dark

18

Nilutamide BBW

Respiratory insufficiency

19

Estramustine MOA

Targeted Alkylator; Estradiol w/ Alkylating Moiety which is a MT inhibitor: promotes dis-assembly and G2/M arrest and produces DNA strand breakage

20

Estramustine Tox

Common: GI upset, gynecomastia, mastalgia, and impotence;
Testosterone levels decreased via negative feedback on HPA;
Due to Estradiol: edema, thromboembolism, MI, PE, stroke;
Elevated hepatic enzymes, hyperbilirubinemia

21

Estramustine Administration

Oral

22

GnRH agonists

Goserelin, Histrelin, Leuprolide, Triptorelin

23

Histrelin Tox

Unique=Seizures & Suicidal Ideation;

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

24

Goserelin Tox

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

25

Leuprolide Tox

Unique=MI/HF

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

26

Triptorelin Tox

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

27

Pregnancy Categories of GnRH agonists

Cat X

28

Goserelin Admin

SC; Initial transient dz flare avoided by 2-4 wks of AR blockers

29

Histrelin Admin

SC; Initial transient dz flare avoided by 2-4 wks of AR blockers

30

Leuprolide Admin

IM/SC; Initial transient dz flare avoided by 2-4 wks of AR blockers