Ovarian/Bladder Cancer Flashcards Preview

Repro Pharm > Ovarian/Bladder Cancer > Flashcards

Flashcards in Ovarian/Bladder Cancer Deck (23)
Loading flashcards...
1

Carboplatin MOA

Forms DNA intrastrand crosslinks and adducts

2

Carboplatin Tox

Allergic platinum rxns; dose-related myelosuppression; cumulative anemia; dose-related N/V; Blood chemistry dyscrasia; elev hepatic enzymes, BUN/Cr

3

Carboplatin Use

Ovarian

4

Cisplatin MOA

Forms DNA intrastrand crosslinks and adducts

5

Cisplatin Tox

Allergic platinum rxns; dose-related severe nephrotox, myelosuppression, & N/V; significant ototox in children

6

Cisplatin Use

Ovarian + Bladder

7

Cyclophosphamide MOA

Pro-drug of active alkylating moiety

8

Cyclophosphamide Tox

Blood Dyscrasia: anemia/infxn; hemorrhagic cystitis (Mesna); N/V; rashes; amenorrhea/infertility; monitor for secondary malignancies; pulmonary fibrosis

9

Cyclophosphamide Use

Ovarian

10

Doxorubicin MOA

Intercalator, free radical generator, topo II inhibitor

11

Doxorubicin Tox

myelosuppression; CHF; hepatic dz; secondary malignancies; extravasational necrosis; N/V

12

Doxorubin Use

Ovarian + Bladder

13

Paclitaxel MOA

MT stabilizer inhibiting depolymerization

14

Paclitaxel Tox

Taxane hypersensitivity; myelosuppression; myalgia/arthralgia

15

Paclitaxel Use

Ovarian

16

BCG MOA

Binds to urothelial cells, activates APCs, induces prod of effector cells (CTL, NK, LAK, BAK)

17

BCG Use

Bladder; 50 mL instillation held for 1-2 hr weekly x6

18

Mitomycin C MOA

Mono- & bi-functional alkylating agent

19

MItomycin C Tox

Pancytopenia (when IV); chemical cystitis; contact dermatitis but also as palmar and plantar erythemas if contact made w/ instillate solution or void volume

20

Mytomycin C Use

Bladder

21

Thiotepa MOA

Polyfunctional alkylator with loss of aziridine (alkylator) moiety

22

Thiotepa Tox

Pancytopenia (when IV); dysuria; urinary retention; chemical/hemorrhagic cystitis; renal dysfxn

23

Thiotepa Use

Bladder