Flashcards in effector mechanisms of humoral immunity Deck (11):
What are the four effector functions of abs against microbes and their toxins?
neutralize antigen, opsonize them for phagocytosis, sensitize them for ab-dependent cellular cytotoxicity, and activate the complement system which are mediated by different Antibody isotypes
A patient infected with Polio will express which mechanism of protective immunity?
neutralization of virus by mucosal IgA antibody
opsonization and phagocytosis is mediated by which antibody?
antibodies against microbes and their toxins do what for the body?
block binding of these microbes and their toxins to cellular receptors
extreme levels of Tissue Necrosis Factor from Endotoxin LPS, causes a condition known as?
Cytokine Storm. from overwhelming amount of cytokines produced and system organ failure and eventually death.
which isotypes are the most efficient opsonins for promoting phagocytosis via the high affinity FcyR1 (CD64)?
IgG1 and IgG3
FcyRIIB receptor is a type of?
SHIP converts ___ to block B cell receptor signaling to inhibit activation?
PIP3 to PIP2 upon FcyRIIB binding
Perforin and Granzyme recruit?
Caspase 3 which induces cell death cascade
Helminthic worms can be killed by a toxic cationic protein, known as?...present in eosinophil granules
Major Basic Protein