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Flashcards in effector mechanisms of humoral immunity Deck (11):
0

What are the four effector functions of abs against microbes and their toxins?

neutralize antigen, opsonize them for phagocytosis, sensitize them for ab-dependent cellular cytotoxicity, and activate the complement system which are mediated by different Antibody isotypes

1

A patient infected with Polio will express which mechanism of protective immunity?

neutralization of virus by mucosal IgA antibody

2

opsonization and phagocytosis is mediated by which antibody?

IgM

3

antibodies against microbes and their toxins do what for the body?

block binding of these microbes and their toxins to cellular receptors

4

extreme levels of Tissue Necrosis Factor from Endotoxin LPS, causes a condition known as?

Cytokine Storm. from overwhelming amount of cytokines produced and system organ failure and eventually death.

5

which isotypes are the most efficient opsonins for promoting phagocytosis via the high affinity FcyR1 (CD64)?

IgG1 and IgG3

6

FcyRIIB receptor is a type of?

Inhibitory signal

7

SHIP converts ___ to block B cell receptor signaling to inhibit activation?

PIP3 to PIP2 upon FcyRIIB binding

8

Perforin and Granzyme recruit?

Caspase 3 which induces cell death cascade

9

Helminthic worms can be killed by a toxic cationic protein, known as?...present in eosinophil granules

Major Basic Protein

10

IgE that coat helminths can bind to FceRI on eosinphils to cause?

degranulation to release major basic protein