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Flashcards in Final exam-transplant immuno Deck (44):
1

Autografts are?

exchanges from one part to another part of the same individual

2

grafts exchanged between different individuals of identical constituites

isografts

3

grafts exchanged between non-identical members of the same species

allograft

4

grafts exchanged from members of different species

Xenograft

5

HLA-antigens are

co-dominantly expressed

6

strong barriers to transplantation are these antigens?

class I HLA-antigens (A and B)

7

What are the most important for transplantation?

Class II- three types
HLA-DR, HLA-DP, HLA-DQ

8

Direct allorecognition involves the T cell recognizing

unprocessed allogenic MHC molecules on graft APC's

9

Indirect allorecognition involves T cell recognizing

processed peptide of allogenic MHC molecules bound to self MHC molecules on host APC

10

this type of rejection is caused by preformed antidonor antibodies and complement activated within minutes to hours

Hyperacute

11

reactivation of sensitized T cells within days of transplant rejection

Accelerated

12

primary activation of t cell in transplant rejection that takes days to weeks. involves cellular and vascular changes due to fibrosis

Acute rejection

13

immunologic and non-immunologic factors that take months to years to reject a transplant

Chronic

14

direct allorecognition pathway is the primary response to

graft transplant

15

the indirect allorecognition pathway is most important in?

Chronic rejection

16

Acute cellular involve the which T cells?

T helper 1

17

Acute vascular humoral involve which T cells?

T helper 2

18

after transplant, donor Dendritic cells migrate to?

lymph nodes

19

Chronic graft rejection occurs due to?

occlusion of blood vessels and ischemia of organ

20

which cells play an important role in triggering an acute rejection?

donor Dendritic cells

21

can CD4 and CD8 contribute to graft rejection?

yes

22

indirect allorecognition pathway contributes to which type of rejection?

acute

23

Does Chronic rejection respond to immunosuppressive therapy?

no

24

Fibrinopeptides lead to vascular permeability (vasodilation) that provide attractant of neutrophils and macrophages in the kinin cascade. Fibrinopeptides are a type of Non-immunological factor associated with?

allograft rejection

25

a test used to test recipient serum for performed antibodies against donor HLAs is?

Cross-matching

26

Corneal transplant, heart valve transplant, and bone/ tendon grafts are NOT important for?

ABO blood matching because of a barrier to transplantation

27

The first step in donor transplantation is?

ABO compatibility because of its strong surface antigens on many tissues

28

Universal donor blood?

type O

29

complement is activated by classical pathway. patient of blood type A received type B blood. what happens?

RBC lysis because of anti-B antibodies on the surface of type A blood group.

30

universal recipient?

AB blood

31

to identify HLAs which test is preformed?

tissue typing

32

success of transplantation is dependent on matching of?

MHC antigens

33

the spleen and lymph node provide a convenient source of?

lymphocytes for HLA typing

34

Microcytotoxicity test detects?

which Donors anti-serum to HLA antigens match the best with the recipient

35

ABO is major antigen and Cross matching is Minor

.....

36

a mixed lymphocyte reaction (MLR) is used in

class II HLA typing

37

you want to determine if the donor cells stimulate proliferation of recipient lymphocytes. you use a?

a mixed lymphocyte reaction (MLR) in class II HLA typing

38

Will proliferation occur in recipient tissue if the class II MHC antigens are different?

no. they MUST be the same for proliferation to occur

39

in Graft vs. Host disease, T cells from the transplanted organ react how?

attack host tissue

40

in host vs. graft disease. T cells from the host react how?

attack the transplanted organ

41

T cells enter the allograft when endothelial cells are activated in

non-immune injury of the graft

42

inability of the host immune system to reject allogenic cells due to the immunocompromised recipient causes?

Graft vs host disease.

43

reaction directed against MINOR H antigens derived from polypmorphc proetin preented CD8......

Graft vs host disease

44

The cornea is an immunologically

privileged site- free from the immune systems effects