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Flashcards in final exam- hypersensitivity Deck (33):
1

immune complex diseases is this type of hypersensitivty

type III

2

T cell mediated disease like Type I DM is this type of hypersensitivity?

Type IV hypersensitivity

3

type of pathologic reactions that is caused by the release of mediators (histamine) from mast cells

Immediate type I hypersensitivity

4

immediate type I produced this antibody against environmental ags

IgE

5

the genetic tendency to develop allergic diseases

atopy

6

activation of Th2 and IgE in response to ag allergens

type I hypersensitivity

7

two phases of Hypersensitivity. 1. histamine reacts in an? cytokines react in?

1. immediate hypersensitivity reaction

2. late phase

8

prolonged smooth muscle contraction is stimulated by?

leukotrienes

9

the hallmarks of immediate hypersensitivity are?

mast cell mediators, acute vascular dilation and smooth muscle contraction.

10

in type II hypersensitivity, which antibodies activate the complement system by the classical pathway?

IgG and IgM

11

IgG abs bind to neutrophil and macrophage Fc receptors and activate these leukocytes resulting in?

pro-inflammatory response

12

C5a is a major?

chemoattractant

13

Graves disease, Rheumatic fever, Pemphigus vulgaris, ITP, Goodpastures syndrome, and Autoimmuno hemolytic anemia, are all types of ?

type II hypersensitivity

14

immune complexes induce vascular inflammation, ischemic damage to the tissues in this type of hypersensitivity

Type III

15

34 yr male comes to the ER with a venomous snake bite to the forearm. patient received Cro-fab, an anti-venom serum. Soon after administration, patient developed systemic vasculitis, nephritis, and arthritis. This best describes what type of hypersensitivity disease?

Serum sickness in a type III hypersensitivity disease

16

in different T cell mediated disease, tissue injury is caused by inflammation induced by cytokines that are produced mainly by?

CD4+ Th1 cells and Th 17 cells.

17

Multiple sclerosis, RA, TIDM, Crohn's disease, contact dermatitis, and chronic infections like Tuberculosis are diseases of this type of hypersensitivity?

Type IV

18

humans may be sensitized for this type of reactions by microbial infection (TB) by contact sensitization (poison ivy) or immunization (Diphtheria and Tetanus toxoid)

Delayed Type Hyper-sensitization by the activation of CD4+ T cells

19

the tuberculin subcutaneous injection elicits a ____ from a purified protein derivative dependent on concentration of antigen

Delayed Type hypersensitivity

20

exposure to Tuberculosis activates which cell? ....

CD4+ Th1 T cells .....

21

Principles of Immunotherapy

IVIG, anti-TNF antibody, corticosteroids, depletion of CD20 antibody for B cells

22

the common subunit for IL-12 and IL-23 is?

P40. anti P40 blocks Th1 and Th 17 responses

23

Anti-IL17 blocks?

inflammation

24

Anti IL-2R blocks?

T cell proliferation

25

CTLA4Ig blocks

costimulation

26

SLE is a type __ hypersensitivity

Type III-prototypic immune complex mediated disease

*lecture slides are wrong. NOT TYPE II

27

the principal diagnostic test for SLE is the presence of?

persistent high level anti-nuclear IgG antibody production

28

Rheumatoid Arthritis mediated by?

mixed type II and III hypersensitivity reactions to the synovial joints patients have circulating IgM or IgG that react with the Fc on their own IgG molecules.

29

what is a major diagnostic factor for RA?

auto-abs called Rheumatoid Factors

30

in pathogenesis of MS, demyelination of oligodendrocytes are caused from?

excess Glutamate

31

major mechanism involved in Type I DM is?

type IV cell mediated by autoantibodies

32

inflammatory bowel disease is linked to

microflora in the gut

33

clinical manifestations of immediate type I hypersensitivity result from actions of mediators secreted by the

Mast cells