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Flashcards in Immune response to microbes Deck (31):
0

C3a and C5a activate?

mast cells

1

C3b is teh major complement protein that activates?

opsonization

2

the major chemotaxic complement protein is?

C5a

3

CRP (C-reactive protein) bind to this at the primary infection stage

bacterial coat polysaccharides

4

chemokines .....attract neutrophils to the site of infection

IL-8/ CXCL8

5

Th2 activates a B cell to convert to plasma form to secrete IgM, clonal expansion, isotype switching to specific antigen. with the use of?

IL-12

6

plasma cells stay in the lymph node after infection and the memory B cells migrate to?

bone marrow.

7

Diphtheria toxin mechanism of action is to?

shut down protein synthesis in infected cells

8

Cholera toxin

ion/water trasnport

9

tetanus toxin

inhibits neuromuscular transmission

10

Diphtheria, Cholera, and Tetanus toxins are types of?

Exotoxins

11

Endotoxins (LPS) of gram negative bacteria is a major activator of?

macrophages, DC's, and endothelial cells

12

pathogenicity of EC bacteria has two principal mechanisms

inflammation and toxin production

13

Exotoxins are associated with this type of cellular damage?

Collateral damage

14

Peptidoglycans from Gram + and LPS from Gram - can activate which pathway?

independent alternate pathway

15

bacteria that express mannose on their surface can activate?

the lectin pathway

16

MAC can be inhibited by?

CD59-the MAC inhibitory protein and the fluid phase vitronectin and S protein

17

Anaphylatoxins are potent proinflammatory molecules generated by the cleavage of?

C4, C3, and C5 into **C3a, C5a, and C4a**

18

Scavenger receptors respond to?

negative charges to promote phagocytosis

19

**CD14 is the coreceptor for?

TLR4 for recognition of LPS

20

Caspase 1released to the EC environment

IL-1beta....

21

killing of microbes inside a phagolysosome is by?

ROS or NO from arginine derivative and through phagocyte oxidase

22

pathogens can defend themselves by producing

Catalase-to convert ROS/RNS to less harmful compounds

23

Humoral immunity is the prinicial

polysacc.....

24

genetic defects in TH17 development and patients who make neutralizing auto-abs specific for IL-17 are?

susceptible to bacterial and fungal infections with a formation of skin abscesses.

25

IFN-gamma

IgG

26

IL-18 induces activation of?

IFN-gamma which in turn further activates macrophages

27

mediators of septic shock

.......

28

the major mechanism used by bacteria to evade humoral immunity is?

variation of surface antigens

29

Naive B cells acquiring viral particles on IgM or IgD process and present viral peptides to?

Th2 cells

30

Th1 become a major source of? in viral infections

IL-2 and TFN-gamma for CTL's