Endo 3 - Thyroid Flashcards Preview

HD3 Endocrine > Endo 3 - Thyroid > Flashcards

Flashcards in Endo 3 - Thyroid Deck (37):
1

Thyroid axis

TRH =>+ TSH =>+ T4, T3

2

T4, T3 inhibits what?

TRH and TSH release

3

anatomy at risk during thyroid surgery

parathyroid glands and recurrent laryngeal

4

cells adjacent to thyroid follicle

C cells - calcintonin

5

source of iodine for humans

diet

6

minimum level of iodine to avoid hypothyroidism

100 ug/d

7

iodine is ingested and then (1) by thyroid and then (2) to iodine by (3)

1) trapped
2) oxidized
3) thyroid peroxidase

8

Thyroid makes (1) and secretes it into colloid, (2) is added to (3) in (1) to make (4)

1) thyroglobulin
2) iodine
3) tyrosine
4) T3, T4

9

how do thyroid hormones circulate?

bound to proteins

10

T/F T3/T4 must be nonbound to be taken up by tissue

T (<.5% actually free)

11

T4 = (1)% and T3 = (2)%

1) 85
2) 15

12

target of thyroid hormone

thyroid receptor on DNA => increased transcription

13

T/F T3 decreases some things in your body

F

14

useful chemistry tests for hypothyroidism

TSH and free T4 (T3 not as good of a test)

15

mild hypothyroidism (high TSH, regular T4) is how prevalent? %

5-15%

16

goiter is likely during primary or secondary hypothyroidism

primary

17

tx of hypothyroidism

T4, goal = normal TSH and free T4

18

too much T3 T4 =

thyrotoxicosis

19

symptoms of T3/T4 excess

weight loss, vasodilation, warm skin, more appetite, bone turnover

20

two types of thyrotoxicosis

hyperthyroidism and thyroiditis

21

chance of a fib in thyrotoxicosis

10%

22

causes of thyrotoxicosis

graves, tsh receptor mutation, viral/immune, iodine, exogenous, excess tsh (rare)

23

hyperthyroid = high/low iodine uptake?

higher iodine uptake

24

cause of thyroid eye disease

buildup of mucopolysaccharides and lymphocytes

25

symptoms of thyroid eye disease

double vision, eye congestion

26

tx of hyperthyroidism

radioactive iodine (70%), anti-thyroid (29%), surgery (1%)

27

anti-thyroid drugs

methimazole and propylthiouracil

28

black box warning of PTU

hepatotoxicity but used in pregnancy

29

rare blood complication of antithyroid drugs

agranulocytosis

30

thyroid hormone levels in thyroiditis initially

very high due to dump of TH (thyrotoxic)

31

causes of thyroiditis

autoimmune, viral, radiation, drugs

32

radioiodine uptake high or low in thyroiditis

low

33

high iodine levels in patients affects radioiodine uptake levels how?

decreases uptake due to competition from other sources

34

thyroid states associated with goiter

hyperthyroidism, primary hypothyroidism (High TSH), euthyroid

35

how does a euthyroid work in goiter?

thyroid is defective but AP secretes more TSH = normal T3/T4

36

HR in thyrotoxicosis`

elevated

37

T/F you can see edema in both hypo and hyperthyroidism

Ta