Endo 7 - Osteoporosis Flashcards
(37 cards)
which bone type has higher turnover
trabecular
when is peak bone mass
20-30 y/o
how is new bone formed after age 25
bone repair in bone forming units (BFU)
which growth factors can affect bone mass
GH, IGF-1
what hormones affect bone mass
low estrogen or testosterone
what does illness, anorexia, and drugs do to bone mass
decreases bone mass
how does nutrition affect bone mass
low ca intake/malabsorption = decrease bone mass
what cytokine is released during bone turnover
IGF-1
how long does osteoclast resorption take
2-3 weeks
how long does osteoblast laydown take
3 months
what event in women causes major bone loss
menopause
how do osteocl break bone down
acid
what stimulates macrophages to differentiate into osteocl
rankL on osteobl activate RANK on macro
what cytokine must be present to turn macro into osteocl
M-CSF
what protein blocks RANK-L on osteobl
osteoprotegrin
what does estrogen to do to osteoprotegrin
increases production of osteoprotegrin
what is main problem with old age bone loss
osteobl can’t keep up with osteocl
what determines bone strength
width and radius
do you lose bone inside or outside
inside
what do glucocorticoids do to bone
block osteob, increase RANKL, increase ca secretion, inhibit estrogen
T/F osteoclast inhibitors restore lost bone
FALSE
effect of denosumab
blocks RANKL
risks of estrogen
stroke, DVT, cancer
raloxine effect
SERM at bone but not uterus/breast
