Endo 7 - Osteoporosis Flashcards Preview

HD3 Endocrine > Endo 7 - Osteoporosis > Flashcards

Flashcards in Endo 7 - Osteoporosis Deck (37):
1

which bone type has higher turnover

trabecular

2

when is peak bone mass

20-30 y/o

3

how is new bone formed after age 25

bone repair in bone forming units (BFU)

4

which growth factors can affect bone mass

GH, IGF-1

5

what hormones affect bone mass

low estrogen or testosterone

6

what does illness, anorexia, and drugs do to bone mass

decreases bone mass

7

how does nutrition affect bone mass

low ca intake/malabsorption = decrease bone mass

8

what cytokine is released during bone turnover

IGF-1

9

how long does osteoclast resorption take

2-3 weeks

10

how long does osteoblast laydown take

3 months

11

what event in women causes major bone loss

menopause

12

how do osteocl break bone down

acid

13

what stimulates macrophages to differentiate into osteocl

rankL on osteobl activate RANK on macro

14

what cytokine must be present to turn macro into osteocl

M-CSF

15

what protein blocks RANK-L on osteobl

osteoprotegrin

16

what does estrogen to do to osteoprotegrin

increases production of osteoprotegrin

17

what is main problem with old age bone loss

osteobl can't keep up with osteocl

18

what determines bone strength

width and radius

19

do you lose bone inside or outside

inside

20

what do glucocorticoids do to bone

block osteob, increase RANKL, increase ca secretion, inhibit estrogen

21

T/F osteoclast inhibitors restore lost bone

FALSE

22

effect of denosumab

blocks RANKL

23

risks of estrogen

stroke, DVT, cancer

24

raloxine effect

SERM at bone but not uterus/breast

25

nasal spray

calcitonin

26

function of bisphosphonates

disrupt OC cytoskeleton

27

t1/2 of bisphos

10 years

28

can you move after you take bisphos

NO - must wait 30-45 min

29

what molecular feature of bisphos makes it hone in on OC

high negative charge

30

rare mouth complication of bisphos

osteonecrosis of jaw

31

major sites of frx in osteoporosis

hip and spine

32

side effect of denosumab

more infections

33

how effecting is denosumab

too effective - turns off bone turnover

34

tx to recruit OB

PTH in pulses

35

how does PTH in pulses cause OB recruitment

OB activation wins out over OC activation

36

major indicator of bone strength

BMD

37

1 SD of BMD change =

2x frx risk