Endo 5 - Lipids Flashcards Preview

HD3 Endocrine > Endo 5 - Lipids > Flashcards

Flashcards in Endo 5 - Lipids Deck (49):
1

major function of triglycerides

fuel

2

major function of cholesterol

hormone synthesis

3

how are lipids txp in blood

lipoproteins duh

4

what is the function of apoproteins

barcode - identification

5

what are the 6 types of lipoproteins

chylomycron, VLDL, chylo remnants, IDL, LDL, HDL

6

if the lipoprotein is low density, what is the predominant molecule

TG

7

which lipoprotein uses ApoA

HDL

8

which lipoprotein allows for LPL to chew off TG

ApoCII

9

what is the ligand for liver ApoB/ApoE receptors

ApoB 100

10

which lipoprotein allows liver to remove chylo remnants, VLDL, and IDL

ApoE

11

T/F ApoE is present in LDL

FALSE

12

if you have 100 apoB, how many particles do you have

100

13

which particle is apoB not present

HDL

14

which is more atherogenic, high # of small particles or small # of large particles

high # of small

15

what is the exogenous pathway for lipid disposal

dietary lipids moved into tissues

16

what is the endogenous pathway for lipid disposal

moves TG and cholesterol made in liver to tissues

17

what is the reverse cholesterol pathway for lipid disposal

moves choles fro mcells back to liver for bile excretion

18

what does hepatic lipase do

lipolizes IDL and HDL

19

what are the two receptors that can clear VLDL, IDL and remnants

Remant receptor and ApoB/E receptor

20

how is LDL cleared from blood

liver ApoB/E receptor

21

what enzyme converts nascent HDL into mature HDL

LCAT

22

what is the action of LCAT

FC into CE

23

how are CE from HDL moved to remnants/vldl/ldl/idl

CETP

24

what is the effect on HDL after inhibition of CETP

increased HDL levels

25

what is exchanged for CE via CETP

TG

26

what is primary hyperlipidemia

genetic

27

how do drugs affect lipid level

increase VLDL (except anabolic steroids - LDL)

28

what does DM do to lipids

increase VLDL

29

what does liver/biliary disease do to lipids

makes abnormal lipoproteins => hyperlipidemia

30

how does hypothyroid cause hyperlipidemia

decreases clearance of lipoproteins

31

how does nephrotic syndrome cause hyperlipidemia

increases apoB production

32

what are 4 ways you can have decreased lipoprotein clearance

bad LPL/ApoCII, abnormal apoB/E, abnormal apoB/E receptor, not enough apoB/E receptors

33

what is an eye-sign of high cholesterol

corneal arcus < age 50

34

what is a periorbital sign of high C/TG

xanthelasma

35

what is a tendon sign of high C

tendinous xanthoma

36

what is a palmar sign of high remnants

palmar xanthoma

37

what is a retinal sign of high chylo

lipemia retinalis

38

what is a cutaneous sign of high chylo

eruptive xanthoma

39

what is a general sign of high TG/low HDL

central obesity

40

how do you calculate VLDL

TG/5 (only if TG < 400)

41

what defect is present in familial hypercholesterolemia (Iia)

LDL receptor defect - associated with ASCVD

42

T/F hypertriglyceridemia is associated with ASCVD

FALSE

43

what is the defect in hypertrigly

VLDL overproduction

44

what is the defect in combined hyperlipidemia

ApoB overproduction

45

defect in hyperchylo

LPL/ApoCII defect

46

drugs that decrease cholesterol production

statins, niacin

47

drugs that increase cholesterol clearance

bile acid - increase LDL receptors

48

drug that decreases chol absorption

ezetimide

49

drug for high TG

fibrates