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Flashcards in Endocrine Deck (38):
1

Somatostatin analog used for acromegaly, pituitary adenoma, and variceal bleeding

Octreotide

2

GnRH analog for ovarian suppression, endometriosis, myoma uteri

Can cause temporary exacerbation of precocious puberty or prostate CA

Leuprolide

3

GnRH antagonist to prevent premature LH surge during controlled ovarian hyperstimulation

Ganirelix

4

Dopamine agonist used for hyperprolactinemia

Bromocriptine

5

ADH antagonist used for SIADH

Conivaptan

6

Levothyroxine's effect for hypothyroidism can be seen how many weeks after therapy?

6-8 weeks

7

Medical emergency representing the end state of untreated hypothyroidism

Myxedema coma

8

Inhibits peripheral conversion of T4-T3

PTU

9

Drug of choice for hyperthyroid pregnant patients

PTU

10

Thioamide that blocks iodine organification

Methimazole

11

Prenatal exposure to methimazole can cause

Aplasia cutis congenita

12

Symptoms preceding agranulocytosis

Sore throat
Fever

13

Prevents radiation induced thyroid damage

Potassium iodide
Lugol's solution

14

Ingestion of iodine causes hypothyroidism

Wolf Chaikoff effect

15

Ingestion of iodine causes hyperthyroidism

Jod Basedow phenomenon

16

Beta blocker that inhibits peripheral conversion of T4 to T3

Propranolol

17

Anti arrhythmic that can cause thyroid disease

Amiodarone

18

Mineralocorticoid used for addison disease, CAH and adrenal replacement therapy

Fludrocortisone
Deoxycorticosterone

19

Glucocorticoid synthesis inhibitor that inhibits desmolase blocking conversion of cholesterol to pregnenolone

Used for breast cancer and cushing syndrome
Abused by body builders

Aminoglutethimide

20

Glucocorticoid synthesis inhibitor and an azole antifungal

Ketoconazole

21

Drug of choice for pregnant patients with Cushing

Metyrapone

22

Synthetic estrogen used for atrophic vaginitis

Can have clear cell vaginal adenocarcinoma in daughters of mothers who took this drug

Diethylstilbestrol

23

Activates progesterone receptors

For HRT and contraception
Prevents estrogen induced endometrial cancer

Norgestrel

24

Progestin used as appetite stimulant

Megestrol

25

Selective estrogen receptor modulator (SERM) that is used for hormone sensitive breast cancer

Tamoxifen

26

Tamoxifen reduces the risk for what type of cancer?

Endometrial

27

SERM that has estrogen agonist effects in liver and bone

Used in osteoporosis

Raloxifene

28

SERM used for induction of ovulation

Can cause multiple pregnancy

Clomiphene

29

Estrogen synthesis inhibitor by inhibiting aromatase

Used for breast cancer and precocious puberty

Anastrozole
Letrozole
Exemestane

30

Ovarian inhibitor, partial agonist of progestin and androgen receptors

Used for endometriosis, fibrocystic disease

Can cause weight gain, acne, hirsutism

Danazol

31

Androgen antagonist for prostate cancer and surgical castration

Flutamide
Bicalutamide
Nilutamide

32

Early morning hyperglycemia:
When the evening dose of intermediate insulin is high, hypoglycemia develops around 3am

Counter regulatory hormones are produced resulting to hyperglycemia pre breakfast

Somogyi effect

33

Treatment for somogyi effect

Decrease dose of evening insulin

34

Early morning hyperglycemia:

When the evening dose of intermediate insulin is low, hyperglycemia both at 3am and 7am

Insulin waning

35

Treatment for waning of insulin dose

Increase dose of evening insulin

36

Early morning hyperglycemia:
Insulin sensitivity becomes low between 6 and 7 am due to growth hormone spike
Mild hypoglycemia in the morning but 3am glucose is normal

Dawn phenomenon

37

Most physiologic strategy in insulin therapy

Basal bolus

38

Secretion of PTH is dependent on the concentration of this ion in the blood

Free ionized calcium