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Flashcards in GIT, Toxicology Deck (32):
1

Neutralizes stomach acid by reacting with protons in the lumen of the gut

Magnesium-Aluminum hydroxide

2

Competitive H2 receptor blocker

Cimetidine
Ranitidine
Famotidine
Nizatidine

3

Highly effective in suppressing nocturnal acid

H2 receptor blockers

4

H2 blocker that can cause gynecomastia

Cimetidine

5

Omeprazole causes irreversible blockade of ______ in active gastric parietal cells

H K ATPase

6

Drug of choice for peptic ulcer disease

Omeprazole

7

Mucosal protective agent that binds to injured tussue and forms a protective covering over ulcer beds

Sucralfate

8

Mucosal protective agent that activates EP receptors that causes HCO3 and mucus secretion in stomach

Also causes uterine contraction

Misoprostol

9

Mucosal protective agent that forms a protective coating on ulcerated tissue, stimulates mucosal protective mechanisms

Black stools, darkening of tongue

Bismuth salicylate

10

Prokinetic agent that blocks D2 receptors that increases intestinal motility and gastric emptying

DOC for DM gastroparesis
Antiemetic

Metoclopramide

11

Bulk forming laxative
Forms indigestible hydrophilic colloids that absorb water which promotes peristalsis

Psyllium
Methylcellulose
Polycarbophil

12

Stool softening laxative that permits water and lipids to penetrate

Can cause malabsorption of ADEK

Docusate
Mineral oil
Glycerin suppository

13

Osmotic laxative that has solube but nonabsorbable compounds, increasing fecal fluid

Can cause electrolyte abnormality

Lactulose
Polyethylene glycol
Mg Oxide
Sorbitol
Mg citrate
Na phosphate

14

Stimulant/cathartic laxative that directly stimulates enteric nervous system

Can cause melanosis coli

Bisacodyl
Senna
Aloe
Castor oil
Cascara

15

Anti diarrheal that activates opioid receptors in enteric nervous system

Can cause paralytic ileus

Diphenoxylate
Loperamide
Colloidal bismuth
Kaolin + pectin

16

Paralytic ileus can be reversed by giving

Betanechol

17

Antiemetic that blocks the chemoreceptor trigger zone and 5 HT3 receptors

Ondansetron
Granisetran
Dolasetron
Palonosetron
Alosteron

18

Immumodulator used for IBD

Not useful for acute flare ups

(5-ASA)
Mesalamine
Balsalazide
Olsalazine
Sulfasadine

19

Organophosphate poisoning

DUMBBELSS

Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation (CNS, skeletal ms)
Lacrimation
Sweating
Salivation

20

Most common cause of death in organophosphate poisoning

Respiratory failure

21

Treatment for organophosphate poisoning

Atropine
Pralidoxime

22

Long term exposure to this herbicide can cause NH lymphoma

Chlorophenoxy acid

23

Most widely used herbicide in the world

Glyphosate

24

Lead poisoning treatment

Oral succimer- OPD
EDTA with or without dimercaprol

25

Treatment for arsenic poisoning

Dimercaprol

26

Treatment for ACUTE INORGANIC mercury poisoning

Dimeraprol or oral succimer

27

Treatment for CHRONIC INORGANIC mercury poisoning

Succimer and Unithiol

Do not give dimercaprol- may redistribute mercury to the CNS

28

Treatment for Iron poisoning

Deferoxamine

29

Treatment for copper poisoning and Wilson's disease

Penicillamine

30

Treatment for severe chronic lead poisoning

EDTA

31

Antidote for opioids

Naloxone

32

Treatment for benzodiazepine overdose

Flumazenil