Parkinsonism, Psych, Opioids, Abuse Flashcards Preview

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Flashcards in Parkinsonism, Psych, Opioids, Abuse Deck (68):
1

Primary drug for Parkinsonism

Levodopa Carbidopa

2

Levodopa is contraindicated in patients with a history of

Psychosis

3

Phenomenon in Parkinson wherr there is alternating periods of inproved mobility and akinesia over a few hours or days during the treatment

On- Off Phenomena

4

Phenomenon in Parkinson where there is deterioration of drug effect in between doses

Due to progressive destruction of nigrostriatal neurons that occur with disease progression

Wearing off Phenomenon

5

Partial agonist at dopamine D2 receptors in thr brain

Used in Parkinson, Levodopda intolerance and hyperprolactinemia

Can cause erythromelalgia

Bromocriptine

6

Antiparkinsonism that is a partial agonist at D3 receptors

Compulsive gambling, hypersexuality overeating

Pramipexole
Ropinirole

7

Antiparkinsonism drug that is a partial D3 agonist

Used for off periods of Parkinsonism

Severe nausea

Apomorphine

8

Patients who are taking apomorphine should take this drug first to prevent severe nausea

Trimethobenzamide

9

Antiparkinsonism drug that partially inhibits MAO B at a certain dose

Can cause serotonin syndrome when used with SSRI TCA Meperidine

Selegiline
Rasagiline

10

COMT inhibitor that blocks L-dopa metabolism and prolongs response to levodopa

Orange urine
Hepatotoxic
Neuroleptic malignant syndrome
Rhabdomyolysis

Entacapone
Tolcapone

11

Drug used to potentiate dopaminergic action

Can cause livedo reticularis

Amantadine

12

Drugs that can cause livedo reticularis

A MAN reads fHM and GQ

Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

13

Anticholinergic drug used for Parkinsons that blocks muscarinic receptors

Used to prevent EPS caused by antipsychotics
Little effect on bradykinesia

Benztropine
Biperiden
Trihexyphenidyl
Orphenadine
Procyclidine

14

This drug is effective in some schizophrenic patients resistant to treatment with other antipsychotics

Clozapine

15

Dopaminergic tract for mentation and mood

Mesocortical-Mesolimbic

16

Dopaminergic tract for extrapyramidal function

Nigrostriatal

17

Dopaminergic tract for control of prolactin release

Tuberoinfundibular

18

Irreversible disorder characterized by repetitive involuntary movements like tongue protrusion and lip smacking

Tardive dyskinesia

19

Typical antipsychotic that blocks D2 receptors

EPS, failure of ejculation, corneal and lens deposits, NMS

Chlorpromazine

20

Only antipsychotic with fatal overdose

Strongest autonomic effects

Thioridazine
Fluphenazine
Perphenazine

21

Typical antipsychotic used for schizophrenia, manic phase of bipolar, Huntington and Tourette

Weakest autonomic effects
Less sedating

Haloperidol

22

Atypical antipsychotic used for refractory schizophrenia

Only antipsychotic that reduces risk of suicide

Clozapine

23

Antipsychotic than can cause agranulocytosis

Clozapine

Watch clozely for agranulocytosis

24

Atypical antipsychotic that can cause weight gain

Olanzapine= Obesity

25

Most sedating atypical antipsychotic

Quetiapine= Quiet- apine

26

Atypical antipsychotic less sedating than quetiapine

Hyperprolactinemia

Risperidone

Rise and Shine
Rise to a pair

27

Only antipsychotic approved for schizophrenia in the youth

Risperidone

28

Atypical antipsychotic that can cause postural hypotension, QT prolongation

Ziprasidone

29

Least sedating atypical antipsychotic

Aripiprazole

30

Features of Neuroleptic Malignant Syndrome

FEVER
Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity

31

Threshold for lithium toxicity

2 meq/L

32

Treatment for lithium overdose

Dialysis

33

Neurotransmitters involved in the expression of mood

NE
Serotonin

34

Antidepressant ( TCA) used for enuresis and MDD not responsive to other drugs

Imipramine

IHI-pramine

35

3 Cs of TCA toxicity

Cardiotoxicity
Convulsions
Coma

36

TCAs mode of action is the blocksde of which transporters?

NE and 5HT

ANS and histamine

37

First line for MDD

Fluoxetine
Paroxitine
Citalopram
Escitalopram
Sertraline
Vilazodone

38

SSRIs can cause serotonin syndrome when used with what drug?

MAOIs

39

SSRI approved only for OCD

Fluvoxamine

40

SSRI that can cause diarrhea

Sertraline
Squirtraline

41

Drugs that can cause erectile dysfunction

A SORE PeniS can't Fuck Hard

SSRI
Opiates
Risperidone
Ethanol, Estrogen
Propranolol
Spironolactone
Finasteride
Hydrochlorothiazide

42

Drugs that can cause priapism

Tigas PeniS Qo, AyaW Bumaba

Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion

43

Tetracyclic antidepressant used for major depression

Mirtazapine

44

Tetracyclic antidepressant that inhibits neuronal reuptake of dopamine and NE

Used for smoking cessation

Bupropion

45

MAOI (Phenelzine) can cause hypertensive crisis when taken with

Tyramine

46

Treatment for NMS

Diphenhydramine

47

Opioid with shortest half life

Remifentanil (3-4 mins)

48

Opioid with longest half life

Buprenorphine ( 4-8 hours)

49

Opioid analgesic against mu receptors

Used for severe pain and adjunct for anesthesia

Morphine

50

Antidote for morphine

Naloxone

51

Opioid that is a strong agonist against mu receptors. Inhibits pain at spinal and supraspinal sites

Used in severe pain, chronic pain, cancer pain

Fentanyl

52

Most potent opioid

Ohmefentanyl

53

Strong opioid agonist at mu and kappa receptors
Used for spasmodic pain

Meperidine

54

Strong opioid agonist at mu receptors

Used for opioid dependence and withdrawal

Methadone

55

Partial opioid agonist at mu and kappa receptors used for chronic, neuropathic and cancer pain

Can cause hypogonadism, hearing loss

Hydrocodone
Oxycodone

56

Partial opioid agonist used for cough suppression

Dextrometorphan
Codeine

57

Weak agonist at mu receptors used for mild to moderate pain and restless legs syndrome

Withdrawn because of fatal cardiotoxicity
Commonly used in suicide

Propoxyphene

58

Mixed opioid agonist-antagonist

Strong agonist at kappa and weak antagonist at mu receptors

Used for alcohol dependence

Nalbuphine

59

Dual acting opioid analgesic
Weak agonist at mu receptors for moderate pain

Lowers seizure threshold, nausea and vomiting

Tramadol

60

Dopamine plays a primary role in the expression of reward in what part of the brain

Mesolimbic system

61

Loss of appetite in methamphetamine use is due to increase in this neurotransmitter

Serotonin

62

Congener of methamphetamine that act as sexual enhancers

MDMA
Ecstasy

63

Treatment for MDMA overdose

Supportive
Hypertonic saline for hyponatremia

64

Known effect of MDMA overdose

Profound hyponatremia

65

Cocaine inhibits CNS transporters of these neurotransmitters

Dopamine
Norepinephrine
Serotonin

66

Cocaine can cause a feeling that insects are crawling under the skin

Delusional parasitosis

67

Most dangerous hallucinogenic agent

PCP
Phencyclidine

68

Active ingredient tetrahydrocannabinol

Dream like state
Tachycardia
Reddened conjunctiva
Dry mouth

Marijuana