NSAIDS, DMARDS, Gout Flashcards Preview

Pharma > NSAIDS, DMARDS, Gout > Flashcards

Flashcards in NSAIDS, DMARDS, Gout Deck (30):
1

Non selective NSAID that prevents uric acid excretion

Aspirin

2

Treatment for aspirin overdose

Activated charcoal/ gastric lavage
Alkalinize urine with bicarbonate

3

Long term use of this drug reduces the risk of colon cancer

NSAIDs

4

Drug that prevents NSAID induced gastritis

Misoprostol

5

Intravenous NSAID that is mainly used for analgesia

Use is generally restricted to 72 hrs only

Ketorolac
Dexketoprofen

6

NSAID used for closure of PDA
Inhibits COX 1 more than COX 2

Indomethacin

7

Limit dose of paracetamol

4 grams

8

Antidote of paracetamol

N- acetylcysteine

9

Most common cause of liver failure

Paracetamol

10

Lethal dose of paracetamol

15g

11

Most common form of chronic inflammatory arthritis

Rheumatoid arthritis

12

DMARD that inhibits AICAR transformylase and thymidylate synthetase

DMARD if choice for rheumatoid arthritis

Methotrexate

13

Rescue agent of Methotrexate

Leucovirin

14

DMARD that inhibits TNF a that is used for Crohns and rheumatoid arthritis

Infliximab

15

DMARD that is a purine analog and forms 6-thioguanine that suppress inosinic acid synthesis

Azathioprine

16

This drug cannot be given with azathioprine because it leads to severe leukopenia

Allopurinol

17

DMARD that can cause hemorrhagic cystitis

Cyclophosphamide

18

Rescue agent for cyclophosphamide

MESNA

19

DMARD that can cause hirsutism, nephrotoxicity and gingival hyperplasia

Cyclosporine

20

DMARD that is used for SLE nephritis, Wegeners and rheumatoid with reversible myelosuppresion

Mycophenolate Mofetil

21

DMARD that inhibits release of cytokines

Used for RA, IBD

Can cause methemoglobinemia, hemolytic anemia, reversible infertility in men

Sulfasalazine

22

Monoclonal antibody that is used for moderate to severe rheumatoid arthritis with Methotrexate in patients with inadequate response to TNF a

Rituximab

23

Monoclonal antibody that binds to IL-6 and used for moderate to severe RA in patients with inadequate response to TNF a

Do not use in patients with Diverticulitis

Tocilizumab

24

Anti gout drug that inhibits microtubule assembly and decreases macrophage phagocytosis

Used also in family Mediterranean fever
Can cause diarrhea, AKI and agranulocytosis

Colchicine

25

This NSAID is not used in Gout due to renal retention of uric acid

Aspirin

26

This drug is commonly used in the initial treatment of gout as a replacement for colchicine

Indomethacin

27

Uricosuric agent that may precipitate acute gout during early phase of drug action

Can cause nephrotic syndrome and aplastic anemia

Probenecid

28

Xanthine oxidase inhibitor that is the first line for chronic gout

Allopurinol

29

Allopurinol can cause this idiosyncratic reaction

Cataract

30

Nonpurine reversible xanthine oxidase inhibitor for chronic gout

Febuxostat