Endocrine Drugs - Thyroid And Antithyroid Drugs Flashcards Preview

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Flashcards in Endocrine Drugs - Thyroid And Antithyroid Drugs Deck (19):
0

What is the mechanism of action of levothyroxine (T4) and liothyronine (T3)?

Activation of nuclear receptors results in gene expression with RNA formulation and protein synthesis.

1

What is the clinical application of levothyroxine and liothyronine?

Hypothyroidism

2

What are the pharmacokinetics of levothyroxine and liothyronine?

1. T4 is converted to T3 in target cells, the liver, and the kidneys.
2. T3 is 10x more potent than T4.

3

What is the mechanism of action of propylthiouracil (PTU) and methimazole?

Inhibit thyroid peroxidase reactions, iodine organification, and peripheral conversion of T4 to T3.

4

What is the clinical application of PTU and methimazole?

Hyperthyroidism

5

How are PTU and methimazole administered?

Orally - delayed onset of activity.

6

What is the toxicity of PTU and methimazole?

1. Nausea
2. GI disturbances
3. Rash
4. Agranulocytosis
5. Hepatitis
6. Hypothyroidism

7

What is the mechanism of action of Lugol's solution and potassium iodide?

1. Inhibit iodine organification and hormone release.
2. Reduce size and vascularity of thyroid gland.

8

What are the clinical applications of Lugol's solution and potassium iodide?

Preparation for surgical thyroidectomy.

9

How are Lugol's solution and potassium iodide administered?

Orally - acute onset of activity within 2-7d.

10

What is the toxicity of Lugol's solution and potassium iodide?

Rare.

11

What is the mechanism of action of radioactive iodine?

Radiation-induced destruction of thyroid parenchyma.

12

What are the clinical applications of radioactive iodine?

Hyperthyroidism

13

How is radioactive iodine administered?

Orally.

14

What is the toxicity of radioactive iodine?

Sore throat, hypothyroidism.

15

What is the mechanism of action of propranolol rag adding thyroid function?

Inhibition of conversion of T4 to T3.

16

What is the clinical application of propranolol?

Thyroid storm

17

What are the pharmacokinetics of propranolol?

Rapid onset of activity.

18

What is the toxicity of propranolol?

1. Asthma
2. AV blockade
3. HTN
4. Bradycardia

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