Review - Immunosuppressive Agents Flashcards Preview

Pharmacology > Review - Immunosuppressive Agents > Flashcards

Flashcards in Review - Immunosuppressive Agents Deck (16):
0

Which agents are signaling inhibitors of B/T-cell proliferation?

1. Cyclosporine A
2. Tacrolimus
3. Sirolimus

1

Name three medications that cause gingival hyperplasia.

1. Cyclosporine
2. Phenytoin
3. Nifedipine

2

What major hepatic enzyme metabolizes cyclosporine A?

CYP3A4

3

Cyclosporine A becomes more effective as an immunosuppressant when combined with what class of drugs?

Glucocorticoids

4

FK506 is also known as?

Tacrolimus

5

Which murine monoclonal antibody interferes with T-cell function by binding to CD3 glycoprotein?

Muromonab-CD3 (OKT3)

6

Give examples of cytotoxic agents used in immunosuppressive therapy?

1. Azathioprine
2. Mycophenolate mofetil
3. Methotrexate
4. Leflunomide
5. Hydroxychloroquine
6. Cyclophosphamide

7

Which cytotoxic agents used in immunosuppressive therapy are pro-drugs?

1. Azathioprine
2. Mycophenolate mofetil
3. Leflunomide

8

Which cytotoxic immunosuppressant is an alkylating agent?

Cyclophosphamide

9

Which immunosuppressant is a derivative of 6-mercaptopurine, antagonizes purine metabolism, and is cytotoxic to lymphocytes?

Azathioprine

10

Which immunosuppressant inhibits inosine monophosphate dehydrogenase, thereby inhibiting de novo guanosine nucleotide synthesis?

Mycophenolate mofetil

11

Which immunosuppressive agents are cytokine inhibitors?

1. Etanercept
2. Infliximab
3. Adalimumab
4. Certolizumab
5. Thalidomide
6. Anakinra

12

Which cytokine inhibitor is NOT a TNF-a inhibitor?

Anakinra - IL-1 receptor blocker.

13

Give two examples of immunosuppressive agents that inhibit costimulation.

1. Abatacept
2. Belatacept

14

Give two examples of immunosuppressive agents that block cell adhesion.

1. Natalizumab
2. Efalizumab

15

Give an example of an immunosuppressive agent that blocks complement action.

Eculizumab

Decks in Pharmacology Class (54):