Review - Cancer Chemotherapeutic Agents Flashcards Preview

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Flashcards in Review - Cancer Chemotherapeutic Agents Deck (34):
0

If a chemotherapy treatment leads to a 4 log-kill reduction, then how many tumor cells would remain if there were 10^10 tumor cells to begin with?

10^6

1

What is the definition of a cell-cycle specific cancer chemotherapeutic agent?

Agent that kills actively dividing cells.

2

Give examples of normal non malignant cells in the body that normally are undergoing rapid proliferation.

1. Bone marrow cells
2. GI mucosal cells
3. Hair cells

3

P-glycoprotein is an ATP-dependent membrane (efflux) transporter that is responsible for what?

Pumping drugs out of the cells (responsible for multidrug resistance of chemotherapeutic agents).

4

What drug causes DCM/cardiotoxicity?

Doxorubicin

5

What drug causes pulmonary fibrosis and pneumonitis?

Bleomycin

6

What drugs cause stomatitis and esophagitis?

1. Methotrexate
2. 5-fluorouracil
3. Dactinomycin

7

What drugs cause hemorrhagic cystitis?

Cyclophosphamide and ifosfamide

8

Which drug causes hemorrhagic diathesis?

Plicamycin

9

Which drug causes peripheral neuropathy, neurotoxicity?

Vincristine

10

Which drug causes Nephrotoxicity?

Cisplatin

11

Which drug causes allergic reactions?

1. Etoposide
2. L-asparaginase

12

Which drugs cause hepatotoxicity?

1. 6-mercaptopurine
2. Busulfan
3. Cyclophosphamide

13

Which drug causes pancreatitis?

L-asparaginase

14

Which drug causes cutaneous toxicity (hand-foot syndrome)?

5-fluorouracil

15

Which drug cause disulfiram-like reactions?

Procarbazine

16

What is the name of the antidote that binds to and inactivates the toxic metabolites responsible for cisplatin nephrotoxiciy?

Amifostine

17

What is the name of the cyclophosphamide and ifosfamide urotoxic metabolite that is responsible for causing hemorrhagic cystitis?

Acrolein

18

What is the name of the antidote that binds to and inactivates acrolein?

Mesna

19

Which iron chelator is used to decrease the incidence and severity of doxorubicin-induced cardiomyopathy in patients with metastatic breast cancer who receive doxorubicin for life?

Dexrazoxane

20

What drug is used as a "rescue medication" in patients taking methotrexate?

Leucovorin - active form of folic acid.

21

What is the mechanism of action of Cytarabine?

Pyrimidine antagonist

22

What is the mechanism of action of 6-mercaptopurine and 6-thioguanine?

Purine antagonists

23

What immunosuppressive drug becomes active only after being converted to 6-mercaptopurine?

Azathioprine

24

Because 6-mercaptopurine is metabolized by xanthine oxidase, its serum levels may be significantly increased when given concomitantly with what other medication?

Allopurinol (xanthine oxidase inhibitor)

25

Give examples of antitumor antibiotics.

1. Doxorubicin
2. Daunorubicin
3. Dactinomycin
4. Pali amylin
5. Bleomycin
6. Idarubicin

26

Are the antitumor antibiotics CCS?

Yes (S-phase)

27

What is the mechanism of action of bleomycin?

Complexes with iron and reacts with oxygen which in turn leads to DNA strand scission.

28

Which phase of the cell cycle is bleomycin specific for?

G2

29

Are the anticancer alkylating agents CCS?

No

30

Which adverse effect is unique to vincristine (from the vinca alkaloids)?

Peripheral neuropathy

31

Which adverse effect is unique to vinblastine?

BMS

32

How are hypersensitivity reactions prevented in patients receiving paclitaxel?

Pretreatment with diphenhydramine and dexamethasone.

33

What is the mechanism of action of l-asparaginase?

Hydrolyzes asparagine to aspartic acid and ammonia, thereby depriving tumor cells of asparagine required for protein synthesis.

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