Endocrine Pancreas Flashcards

(47 cards)

1
Q

Somatostain receptors are present in the pancreas which is a ______ effect

A

paracrine

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2
Q

gamma cells

A

pancreatic polypeptide

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3
Q

GLUT 1 transports glucose:

A

across BBB

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4
Q

sympathetic stimulation = ________ insulin

A

decreased

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5
Q

in the process of glucose stimulating the release of insulin, glucose-6-phosphate oxidation causes:

A

increased ATP which closes K+ channels, which depolarizes the cell membrane

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6
Q

increased protein = _______ insulin

A

increased

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7
Q

What does somatostatin do?

A

inhibits digestive function

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8
Q

beta cells

A

insulin, amylin

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9
Q

GLUT 3 transports glucose:

A

into neurons

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10
Q

How can we measure insulin quantity in the urine

A

c peptide

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11
Q

What are the 2 causes of diabetes type 1

A
  1. autoimmune ( T lymphocytes destroy B cells)

2. idiopathic

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12
Q

proglucagon is proteolytically processed to yield:

A

glucagon

incretin (GLP1)

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13
Q

Why does polydipsia occur in chronic diabetes

A

compensate for effects of dehydration

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14
Q

epsilon cells

A

ghrelin

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15
Q

Glucagon has ____ effect on blood amino acids

A

minimal!

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16
Q

in the process of glucose stimulating the release of insulin, how does glucose enter the cell

A

via GLUT 2 via facilitated diffusion

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17
Q

increased incretins (GI hormones) = ______ insulin

A

increased

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18
Q

glucose detection is in the ________ in the hypothalamus

A

arcuate nucleus

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19
Q

What does amylin do?

A

acts on CNS to suppress appetite

20
Q

How does diabetes inhibit growth rates in children

A

due to a shift towards protein catabolism

muscle atrophy and weight loss and no growth

21
Q

Why do cells of the body shrink in chronic diabetes

A

due to an osmotic shift of water into ECF and the blood (from dehydration)

22
Q

alpha cells

23
Q

Proinsulin cleaves to form:

A

c peptide

a-chain + B-chain connected by 2 disulfide bonds

24
Q

glucagon primarily targets the:

A

liver

to stimulate hepatic glucose output

25
delta cells
somatostatin
26
parasympathetic stimulation = _______ insulin
increased
27
What does pancreatic polypeptide do?
putatively reduces appetites and food intake
28
Which GLUT transporter is the only one dependent on insulin
GLUT 4
29
What is the consequence of low levels of insulin secretion?
GLUT-4 can't get to the cell surface, can't bring glucose into the cell
30
GLUT 2 transports glucose:
in kidney and intestine
31
What is the cause of diabetes type 2
life style choice
32
What are the two ways hypoglycemia from insulin excess can occur
1. self-administered insulin overdose | 2. reactive hypoglycemia
33
Your patient has lost consciousness from insulin excess. Before giving them a sugary snack, what do you need to do?
make sure it is insulin overdose and not reactive hypoglycemia check c-peptide levels
34
in the process of glucose stimulating the release of insulin, what happens because of K+ channels closing and depolarizing the cell membrane?
voltage gated Ca2+ channels open Ca2+ enters B-cell
35
Where is proinsulin cleaves to insulin and c-peptide
inside secretory granules
36
What stimulates the release of somatostatin
high fat, carbs, and protein-rich meals
37
in the process of glucose stimulating the release of insulin, how does glucose become "trapped" in the cell
by becoming glucose-6-phosphate
38
Why does polyphagia occur in chronic diabetes
increased appetite due to cells starving because glucose can't get into the cell
39
What happens to nerve cells in chronic diabetes
lose their ability to maintain correct membrane potentials and form action potentials
40
growth hormone effect on blood glucose
stimulates glucose to stay in the blood for the brain to use while other tissues are using lipids and protein to grow
41
Other than hypoglycemia, what else can stimulate the release of glucagon
1. epinephrine 2. CCK 3. vagal stimulation 4. fasting 5. exercise
42
What is primarily responsible for regulating food intakes and body composition
hypothalamic brain centers
43
in the process of glucose stimulating the release of insulin, what triggers exocytosis of insulin vesicles?
Ca2+
44
In the absence of carbohydrates in the diet, what can stimulate glucagon release?
dietary protein (arginine)
45
What does somatostatin inhibit outside of the pancreas
inhibits release of growth hormone by the anterior pituitary
46
GLP1 is released from intestine in response to:
high glucose levels in the intestinal lumen | increases insulin release!
47
What is the most common type of all endocrine disorders?
diabetes mellitus