Endocrine Pancreas Flashcards
(47 cards)
Somatostain receptors are present in the pancreas which is a ______ effect
paracrine
gamma cells
pancreatic polypeptide
GLUT 1 transports glucose:
across BBB
sympathetic stimulation = ________ insulin
decreased
in the process of glucose stimulating the release of insulin, glucose-6-phosphate oxidation causes:
increased ATP which closes K+ channels, which depolarizes the cell membrane
increased protein = _______ insulin
increased
What does somatostatin do?
inhibits digestive function
beta cells
insulin, amylin
GLUT 3 transports glucose:
into neurons
How can we measure insulin quantity in the urine
c peptide
What are the 2 causes of diabetes type 1
- autoimmune ( T lymphocytes destroy B cells)
2. idiopathic
proglucagon is proteolytically processed to yield:
glucagon
incretin (GLP1)
Why does polydipsia occur in chronic diabetes
compensate for effects of dehydration
epsilon cells
ghrelin
Glucagon has ____ effect on blood amino acids
minimal!
in the process of glucose stimulating the release of insulin, how does glucose enter the cell
via GLUT 2 via facilitated diffusion
increased incretins (GI hormones) = ______ insulin
increased
glucose detection is in the ________ in the hypothalamus
arcuate nucleus
What does amylin do?
acts on CNS to suppress appetite
How does diabetes inhibit growth rates in children
due to a shift towards protein catabolism
muscle atrophy and weight loss and no growth
Why do cells of the body shrink in chronic diabetes
due to an osmotic shift of water into ECF and the blood (from dehydration)
alpha cells
glucagon
Proinsulin cleaves to form:
c peptide
a-chain + B-chain connected by 2 disulfide bonds
glucagon primarily targets the:
liver
to stimulate hepatic glucose output