Adrenal Medulla Flashcards
dopamine enters _______ and is converted to norepinephrine by _______
Catecholamine effect on pupils?
Catecholamine effect on alertness?
What is the rate limiting step of catecholamine synthesis
tyrosine hydroxylase converting tyrosine to DOPA
Catecholamine effect on GI activity?
synthesis of catecholamines occurs in the ____ cells
What are the two main enzymes of catecholamine degradation?
- monoamine oxidase (MAO)
2. Catechol-O-methyltransferase (COMT)
What is the only cause of HYPERfunction of adrenomedullary catecholamine synthesis
monoamine oxidase (MAO) converts norepinephrine into __________ and is then excreted in the urine as __________
MHPG - 3-methoxy-4-hydroxyphenylglycol
VMA - 3-methoxy-4-hydroxymandelic acid
Pheochromocytoma produces catecholamines ___x more than normal
tyrosine hydroxylase converts ______ to _______
which part of the cell?
tyrosine to DOPA
Which enzyme predominantly degrades epinephrine?
Chronic stress activates which enzyme in the pathway of catecholamine synthesis
increased expression and concentration
(acute stress = activity of TH)
Catechol-O-methyltransferase (COMT) degrades which catecholamine?
Catecholamine effect on bronchioles?
phenylethanolamine-N-methyltransferase “PNMT” is regulated by: