Chronic Diabetes Flow Chart Flashcards
What happens once ventilation can no longer compensate for metabolic acidosis from increased blood fatty acids and ketosis
diabetic coma
severe acidosis = depress brain function
What causes dehydration
polyurea from osmotic diuresis from glucosuria from hyperglycemia
what contributes to the existing hyperglycemia problem NOT from glucose
gluconeogensis from blood amino acids from decreased cellular amino acid uptake and increased protein degradation
What is the specific cause of the decrease in intracellular glucose
decreased glucose uptake by cells
low blood volume leads to:
low cerebral blood flow
renal failure
What is the cause of glucosauria
hyperglycemia- proximal tubules cannot keep up with filtration, glucose lost in the urine
what causes increased blood fatty acids
increased lipolysis
decreased triglyceride synthesis
What specifically causes the symptom of polyphagia
decreased intracellular glucose
increased blood amino acids is a results of
decreased cellular amino acid uptake
increased protein degradation
insulin deficiency effects on protein
decreased cellular amino acid uptake
increased protein degredation
Insulin deficiency leads to
(increased/decreased) triglyceride synthesis
(increased/decreased) lipolysis
decreased triglyceride synthesis
increased lipolysis
What is the cause of polydipsia
an attempt to compensate for effects of dehydration
metabolic acidosis causes what compensatory mechanism to occur, why?
****it does not always occur tho…
increased ventilation
to ventilate CO2 to shift pH up
in children, how is proerp growth compromised?
increased protein degradation leads to muscle wasting leads to weight loss
What causes polyurea
osmotic diuresis from glucosuria from hyperglycemia
What is the cause of osmotic diuresis
glucosauria from hyperglycemia
Ketone bodies in the blood do what
disrupt blood pH resulting in a metabolic acidosis
What is the result of cellular shrinking from dehydration?
nerve cell malfunction due to an osmotic shift of water into ECF and the blood
How do nerve cells malfunction from cellular shrinking
nerve cells lose their ability to maintain correct membrane potentials and form action potentials
dehydration leads to what three things:
polydypsia
low blood volume
cellular shrinking
what causes an increase in gluconeogensis
increased blood amino acids
What is the cause of ketosis
hepatic use of fatty acids from large-scale mobilization of fatty acids from triglyceride stores
Hyperglycemia results from what two things
- inadequate uptake of glucose into cells
- increased output of glucose from the liver
Why does renal failure occur with low blood volume
GFR declines due to inadequate filtration pressure
Increased protein degredation leads to
muscle wasting
weight loss
