Endocrine-Pharm Flashcards Preview

USMLE > Endocrine-Pharm > Flashcards

Flashcards in Endocrine-Pharm Deck (15):
1

Insulins

Lispro, aspart, NPH, Glargine, Detemir

2

Sulfonylureas

Glyburide, Glimepride, Glipizide; potentiate insulin release by K+-ATPase binding; Weight gain, hypoglycemia

3

Metformin

decreases gluconeogenesis from liver; no weight gain, helps improve lipid profile, but potential for lactic acidosis(renal, heart, or liver problems are risk factors for lactic acidosis) alcohol potentiates these effects too

4

Thiazolidinediones

Pioglitazone, rosiglitazone; induces PPAR-gamma to increase insulin sensitivity; Weight gain and heart failure

5

Pramlintide

amylin analog. Decreases hunger, delays emptying, decreases glucagon; hypoglycemia, nausea, diarrhea

6

GLP-1 analog

Exenatide;has central effects that reduce hunger and lead to weight loss; increases insulin and decreases glucagon release. Nausea, vomiting, pancreatitis

7

Amylin

Delays glucagon secretion

8

Propylthiouracil

inhibition of peroxidase. Propylthiouracil also blocks 5'-deiodinase in peripheral tissues.; for hyperthyroidism; agranulocytosis (rare)

9

octreotide

Somatostatin;; for acromegaly, carcionoid, gastrinoma, glucagonoma

10

demeclocycline

ADH antagonist (member of tetracycline fam); for SIADH; nephrogenic DI toxicity, photosensitivity and abnormalities of bone and teeth

11

glucocorticoids

hydrocortisone (chemically identical), prednisone, triamcinolone (topical), beclomethasone (inhaled), Fludrocortisone (mineralocorticoid activity)

12

Levothyroxine, triiodothyroxine

Thyroxine replacement; myxedema and hypothyroidism; tachycardia, heat intolerance, tremors etc.

13

Other therapies for hyperthyroidism

Beta blockers can rapidly releive thyroid storm symptoms. Potassium Iodide can help inhibit release of thyroid hormone but be careful for thyroid escape

14

Stagliptin

Inhibits DPP-IV (dipeptidyl peptidase 4) who's job is to breaks down incretins (GLP-1) released by the gut in response to a rise in intestinal glucose

15

Meglitinides

Similar to sulfonylureas but are taken before meals (vs. once a day), however they are less likely to produce hypoglycemia