Endocrinology (3B) Flashcards
(21 cards)
Cortisol has major actions and controls ___.
secretion
Its general function is it affects ___ of glucose and hence the name of ___corticoids.
metabolism, gluco
Secretion of cortisol increases during ___ situations and maintains/ protects the body in these conditions.
stressful
Small amounts of cortisol has permissive action on ___ and _____ that exerts control on vascular tone to maintain __ ___ at a normal level.
EP, NE, blood pressure
Major actions of cortisol includes metabolic effects of:
- increase in blood glucose (hyperglycemia)
- increase in glucose availability in CNS
- decrease glucose utilization in peripheral tissues
- increase glucose formation in liver (gluconeogenesis)
- increase glycogen synthesis in liver
- increase in protein breakdown
- increase in fat breakdown
Hepatic glucose production occurs in ___ meals.
in
Glucose is not taken up in ___ and ___ instead they are broken down into their smaller components.
protein, fats
Glucose is made in the process of ____.
gluconeogenesis
Cortisol has a very strong effect on our ___ system.
immune
Cortisol allows the immune system to reduce in hyper___ and unnecessary ____.
activation, inflammation
Cortisol will decrease the ____ number and decrease in lymph node size. It reduces humoral and ___ immunity.
It decrease production of inflammatory substances such as leutrokines and ___.
It decreases capillary permeability and prevent to neutrophil ____ to site of infection and edema.
Reduction in proteolytic content release from ___ and increases susceptibility to infection.
lymphocyte, cellular
prostaglandins
diapedesis, lysosomes
The pharmological use of cortisol is to suppress organ ___ after transplantation.
rejection
Cortisol it’s important in the fetal and neonatal life:
required for the development of the ___
GIT, ____ gland
lungs ___ synthesis
CNS, adrenal, surfactant
Diurnal rhythm and decreased ___ supply alongside ___ deprivation are stress factors.
oxygen, sleep
Cortisol has a negative feedback on ____ and ___. On the pituitary it decreases the ___ of the cells.
hypothalamus, anterior pituitary, responsivity
Too much aldosterone
Conn’s Syndrome
Too little aldosterone
Addison’s disease
Too much of cortisol
Cushing’s disease
Too little cortisol
Addison’s disease
Too much adrenal androgens
Virilizarion (masculination) in females
Too little adrenal androgens
Reduced hair growth and decreased sexual response
