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Flashcards in Endocrinology Deck (79)
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1

additional finding in kallman syndrome

RENAL AGENESIS in 50%

2

growth hormone deficiency in adults

RARELY have symptoms,
subtle signs
- central obesity
- increased LDL and CH levels
- reduced lean mass

3

GH levels low

NOT that helpful since GH is pulsatile and maximum at night

4

confirming low GH

no response to arginine infusion
no response to GHRH

5

prolactin levels low confirmatory Dx

no response to TRH

6

metyrapovnse normally causes...

ACTH to rise, since inhibits 11 beta hydroxyls, thus decreasing output of the adrenal gland

7

before starting thyroxine what should you do,, for panhypopituitarism,,,,

CORTISONE before thyroxine

8

additional info for PC acromegly

carpal tunnel
body odour
colonic polyps
arthralgias
HTN

9

what can give a similar picture as acromegaly

GH abuse

10

best initial test for acromegaly

IGF-1

11

when should MRI be done in acromegaly

AFTER laboratory identification of acromegaly

12

what is co-secreted with GH

PRL

13

possible drugs for tx of acromegaly

cabergoline: DA agonist, inhibits GH release
octreotide or lanreotide: somatostatin inhibits GH release
PEGVISOMANY

14

PEGVISOMANT

GH receptor antagonist-- inhibits IGF release from the liver

15

physiologic causes of hyperPRL

- pregnancy
- intense exercise
- renal insufficiency
- increased chest wall stimulation
- cutting pituitary stalk-- no dopamine-- no inhibition of PRL

16

drug causes of hyperPRL

- antipsychotic meds
- methyldopa
- metoclopramide
- opiods
- TCA's
- verapamil

17

ONLY CCB to cause hyperPRL

VERAPAMIL

18

first thing necessary to do if patient has hyperPRL

PREGNANCY TEST

19

work up for hyperPRL

- TFTs
- Bun/Cr (since kidney insuff elevates PRL)
- LFTs (since cirrhosis elevates PRL)

20

which dopamine agonist is preferred for tx of hyperPRL

CABERGOLIN

21

when to tx hypothyroidism

High TSH (X2) + normal T4

22

when to decide on thyroid replacement in hypothyroidism

anti-TPO when TSH high, and T4 normal

23

involuted non palpable thyroid

exogenous thyroid hormone use

24

low TSH and decreased RAIU

- subacute thyroiditis-- painful
- painless "silent" thyroiditis
- exogenous thyroid hormone use

25

tx of silent thyroiditis

NONE

26

tx of subacute thyroiditis

ASPIRIN

27

which thiourea drugs is preferred for hypthyeroidism

METHIMAZOLE

28

tx of graves opthalmopathy

STEROIDS

29

what must you do if FNA says follicular adenoma

REMOVE SURGICALLY-- since can't tell if benign or malignant from FNA alone

30

90% of hypercalcemia seen in

CANCER PATIENTS