Exam 1 : L24

Question 1

Psoriasis (Type 4 hypersensitivity)

Answer 1

• autoreactive T cells against skin associated antigens
• inflammation of skin with formation of scaly

Question 2

Rheumatoid arthritis (Type 3 hypersensitivity)

Answer 2

• autoreactive T cells and autoantibodies against antigens localized in the joint synovium
• joint inflammation and destruction causing arthritis

Question 3

Graves Disease (can cross placenta) - MHC

Answer 3

• autoantibodies against the thyroid stimulating hormone receptor
• hyperthyroidism: overproduction of thyroid hormones

Question 4

Hashimoto’s disease- MHC disease

Answer 4

• autoantibodies and autoreactive T cells against thyroid antigens
• destruction of thyroid tissue leading to hypothyroidism: underproduction of thyroid hormones

Question 5

Systemic Lupus Erythematous- MHC disease

Answer 5

• autoantibodies and autoreactive T cells against DNA, chromatin proteins, and ubiquitous ribonucleoprotein antigens
• glomerulonephritis, vasculitis, rash

Question 6

Sjogren syndrome- MHC disease

Answer 6

• autoantibodies and autoreactive T cells against ribonucleoprotein antigens
• lymphocyte infiltration of exocrine glands, leading to dry eyes, and/or dry mouth; other organs may be involved, leading to systemic disease

Question 7

Crohn’s disease - MHC/ type 4 hypersensitivity

Answer 7

-autoreactive T cells against intestinal flora antigens
- intestinal inflammation and scarring

Question 8

Multiple sclerosis (Type 4 hypersensitivity)- MHC

Answer 8

• autoreactive T cells against brain and spinal cord antigens
• formation of sclerotic plaques in brain and spinal coord with destruction of myelin sheaths surrounding nerve cell axons, leading to muscle weakness, ataxia, and other symptoms

Question 9

Type 1 diabetes (Type 4 hypersensitivity) - MHC

Answer 9

autoreactive T cells against pancreatic islet cell antigens

Question 10

Ankylosing spondylitis - MHC

Question 11

Goodpasture’s syndrome (Type 2 hypersensitivity)- MHC disease

Answer 11

non- collagenous domain of basement membrane collagen type 4

• glomerulonephritis, pulmonary hemorrhage

Question 12

Myasthenia gravis- MHC

Answer 12

• anti-acetylcholine receptor.. bind in the NMJ..attacks it
• muscle weakness

Question 13

Addison’s disease - MHC disease

Question 14

Pemphigus vulgaris

Answer 14

• epidermal cadherin
• anti desmoglein-3
• blistering of skin