Exam 3 - other musculoskeletal diseases Flashcards Preview

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Flashcards in Exam 3 - other musculoskeletal diseases Deck (35):
1

Reiter syndrome

-seronegative spondylarthritis
-** Chlamydia trachomatis
(can't see, can't pee, can't climb a tree)

2

Achilles periostitis

-radiologic sign of Reiter syndrome
-bone at junct of Achilles and plantar fascia

3

Circinate balanitis

-rash on penis
-due to Chlamydia

4

Septic arthritis: infectious

-seronegative spondylarthritis
- causative agents helps identify treatment!!
-most common nongonococcal cause = S. aureus
-most common in urban areas = gonorrhoeae

5

Lyme disease

(Septic arthritis?)
-Northeast or midwest
-From Borrelia burgdorferi
-carried on ticks found on deer
-hangs out on skin, CNS, joints, heart, eyes
-get rash first, then joint pain, and then CNS stuff

6

Getting septic arthritis from dog and cat bites

-due to pasteurella multocida
-cats more likely due to teeth

7

If you have sickle cell disease and get a bone infection it is mostly due to what bug?

-salmonella paratyphi

8

when you get TB in the spine it is called

Pott disease

9

infection of bone due to stepping on a nail with rubber bottom shoes caused by

P. aeruginosa

10

Osteomyelitis pathology

-bacteria in blood
-spreads to bone
-causes neutrophils to invade
-neutrophils destroy bone with enzymes

11

Osteomyelitis: sequestra vs involucrum

-sequestra = devitalized bone (dead)

-involucrum = reactive bone formation

12

Osteochrondroma = most common what

benign tumor of bone

13

osteoma associated with

gardner syndrome (polyps in colon?)

14

osteoid osteoma: pain

-pain at night
-stopped with ASA

15

osteoblastoma

-characteristics similar to osteoid osteoma

-ASA wont help!

16

Multiple myeloma

-cancer of plasma cells
-diagnose with electrophoresis

17

Risk factors: paget, retinoblastoma, irradiation, fibrous dysplasia

= osteosarcoma

18

X-ray shows codman triangle and sunburst

= osteosarcoma

19

Ewing sarcoma

-small, round cells
-young males
- prox femur, pelvis, rib
- "onion skin" appearance on xray

20

Osteogenesis imperfecta

(aka brittle bone disease)
-defect in type 1 collagen synthesis
-autosomal dominant
-blue sclera, deafness, fractures at birth
-treat with: bisphosphonates

21

Osteopetrosis: marble bone disease

- defect in osteoclast resorption
- leads to skeletal sclerosis
-(usually a carbonic anhydrase II deficiency)
-no treatment

22

have normal head, spine with short arms and legs
-mutation in FGFR3

Achondroplasia

23

Fibrous dysplasia

medullary bone replaced by fibrous tissue

24

Neuropathic Arthropathy

-noninflammatory
-loss of proprioception and deep pain sensation

25

Avascular necrosis

-loss of blood supply
-common in femoral head, scaphoid, digits

26

avascular necrosis to the femoral head in kids

Legg-Calve-Perthes disease

27

Apophysitis

-inflammation of the apophysis
-commonly due to overuse, growth, traction apophysitis

28

Osgood-Schlatter

apophysitis of the tibial tuberosity

29

Sinding-Larsen-Johansson

Apophysitis of inferior patella

30

Sever's disease

apophysitis of calcaneus

31

Iselin's disease

apophsitis of 5th metatarsal

32

Tetanus

-spores enter wound. eventually get to CNS
-lockjaw
-Treat: prevent, debride, etc

33

Duchenne MD

-frameshift mutation
-get **pseudohypertrophy of calves
-Gower maneuver (hands on knees)

34

Myotonic dystrophy

-autosomal dominant
-atrophy of type 1 fibers
-no treatment

35

Myasthenia gravis

-antibody against ACh receptors.

-ptosis
-muscle weakness
-dysphagia