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BASIG q1 > exam 8b > Flashcards

exam 8b Flashcards

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1
Q

another name for spore

A

conidia

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2
Q

tichopytin made of
describe each componenet

A

galactomannan peptide
crude ag of dermatophytes
-cho componenet is immediate response
-peptide is delayed response

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3
Q

Dermatophyte test that is red in color shows

A

dermatophyte

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4
Q

ring worm of scalp Tineacapitis causative agent

A

M. Canis (black dot ring worm)- dermatophyte

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5
Q

cataneous fungi- malassezia furfur
patho and morphology and epidem

A

aka tinea cersicolor
morphology: short unbranched hyphy sphegetti and meatballs
patho: depifment or hyperpigment
epidem: world wide

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6
Q

Cutaneous fungi
morphology
epidemiology
pathogenicity
identification

A

aka tinea nigra
morphology: dimorphic yeast and mold grow in salt
epidemiology : tropical
pathogenicity : brown lesions
identification: KOH and microsopy

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7
Q

pediculosis?

A

caused by pediculus hamanus or lice

sucks blood

connects to hair

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8
Q

what are they
where are they found

A

bizzozero
found in the spinosum
desmosomes that connects cytoplasmic processes

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9
Q

basale
production:
mitotically active/inactive:
cell junctions:
cell shape:

spinosum
production:
mitotically active/inactive:
cell junctions:
cell shape:

A

basale
production: vit d
mitotically active/inactive: active
cell junctions: hemi and desmosome
cell shape: cuboidal to columnar

spinosum
production: vit d
mitotically active/inactive: inactive
cell junctions: desmosomes
cytoplasmic spines
cell shape: cuboidal to squamous

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10
Q

psarisis happens due to what

A

basale rapid proliferation

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11
Q

granulosum
thickness:
cell type:
nuclei?

corneum
thickness:
cell type:
nuclei?

A

granulosum
cell amount: 1 - 3 layers
cell type: squamous cell
nuclei? yes

corneum
thickness: karatinized multiple cells
cell type: squamous
nuclei? no

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12
Q

the follow can be seen in light microscopy or Electron microscopy

Basal Lamina

reticular lamina

basement membrane

A

EM
-basal lamina
-reticular lamina

light
basement membrane

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13
Q

name two parts of dermis and differentiate them

A

Papillary
-loos connective tissue
-more cells
-ground substance
-thin collagen 1 and 3
thin elstic fibers

Reticular
-dense irregular connective tissue
-lee cellular
- closely packed fiber bundles
thick collagen 1
- thick elastic fibers

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14
Q

what is this and where are they located

A

langer lines
cut perpendicular so faster healing , fiber arrangement of dermis
dermis

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15
Q

what are these and where are they located

A

keratohyaline granules (blue)

-they give kerotized feature of stratum
-mostly found in granulosum

lamella bodies (red)
-produce water barrier
-located between granulosum and corneum

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16
Q

what is this and its locations

A

hemidesmosomes
-what they do : tether keratinocytes to basal lamina
-where they are: basale

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17
Q

what is this and its locations

A

desmosome
-what they do : tether keratinocytes together
-where they are: spinosum

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18
Q

what is this
red
blue
where are they derived

A

red melanocyte - derived from nueral crest
melanocyte granules

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19
Q

what cell and what are the rod shapped things
where is this cell located

A

langerhan
-APC
-Spinosum

rod
- birbeck ganules that is made by lectin langerin
-they can internalize and degrade HIV

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20
Q

Merkel cell
what is it?
derived from ?
abundant where?
layer of skin?

A

Merkel cell
what is it? cell for sensation tactile
derived from ? ectoderm
abundant where? finger tips
layer of skin? basal

synapse with pseudounipolar nuerons

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21
Q

what is the blue and what cell

A

cytoplasmic processes of
langerhan
-APC
-Spinosum

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22
Q

what is this and where is it located

A

pacinian corpuscle
for deep pressure vibrations
located at bottom of dermis

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23
Q

what is this and where is it located

A

meissner corpuscle tactile for tactile
upper dermis

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24
Q
A
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25
memorize
26
memorize ... this is part of what kind of gland
eccrine
27
28
associated with staph. aureus or streptococcus pyogene -tsst1 -stss -nonbollous impetigo -necrotizing facitis -local infecion -spreading infection -protein A - protein M -spe -acute rheumatic fever -type 2 necrotizing fascitis -type 1
-tsst1 - s. aureus -stss - step. pyrogen secondary to spe M prtotein -nonbollous - strep py -necrotizing facitis -strep py -local infecion - s. aureus -spreading infection - strep py -protein A - s. aureus binds to Fc of IgG - protein M - strep py... bind to cell stop phago cytosis -spe - strep -acute rheumatic fever - strep -type 2 necrotizing fascitis - strep -type 1. staph aur. and mixed anerobic and aerobic
29
what is munro micro abscesses located and with which dz
epidermis and dermal infiltrates psoriasis
30
clumping factor vs coagulase
clumping -cell wall protein binds firinogen and convert to fibrin for aggregation coagulase binds to prothrombin and converts it to fibrinogen to clot and avoid immune -free protein -tissue distruction ex: hyaluronidase catase etc -staphylokinase (fibrinolysin) : dissolves clot penicillinase
31
what dz fishlike staining with immunofluorecsence IGG immunoglobulins around epidermal cell
pemphigus vulgaris faccid bullae located oral and trunk suprabasal with basal intact
32
what is propionibacterium
it causes actne pleomorphic aerotolerant anaerobe folliculitis boil carbuncle
33
non inflammatory acne inflammatory acne
non inflammatory acne -microcomedome (black and white heads) inflammatory acne - follicular contents repture to dermis -papule -pustules -nodule
34
folliculitis furuncles vs carbuncle what causes it which one is associated with hot tub
-s aureus majority -p. aeruginosa G - *** associated with hot tub) furuncle is boil enlarge folliculitis carbuncle is muttiple hair follicles (dermis and sub)
35
cause of gas gangreen? another name type of toxin released
myonecrosis - clostridium perfringens (anerobic) -spor forming g + anaerobic bacillus alpha toxin phospholipase c a leithinase lyse of cells increase entropy of heart histamine release
36
erythema nodosum is a type of what
panniculitis inflammation of fat unknown cause but can be drugs infection sarcoidosis ulcerative colisitis malagnancy
37
biopsy shows muscle necrosis and gram variable and manifest of bronze, clear read blue bumps in three days of innoculation
myonecrosis or ganggreen
38
blepharo conj is what type of infection and what pathogen causes it
it is a pyrogenic caused by staph
39
transient rapid rash with raised papules to erythematous plaque how long does it take to form
urticaria (hives) fides within a day and happens within hours
40
red papules and vescicles oozing and crusted skin lesions spongiotic dermatitis eosinophils may be present
eczematous dermatitis
41
types of eczematous dermatitis how long does it take to form
atopic type 1 HSR asthma related or allerges allergic contact dermatitis type vour hyper sensitivity poison ivy and other agents nickle etc happens 48 to 72 hours of contact and stays for 2-4 weeks drug photoexzematous primary irritant dermatitis
42
macules papules vesicles and bullae target lesions symetrical distribution on extremeties ..... how long does it take to form
erythema multiforme 2 weeks to a monthand goes away after a few weeks caused by infection and druvs self limited interface dermatitis is milder form
43
immuno fluorescence shows linear pattern immunoglobulin and compliment at basment membrane. dermo epidermal junction
bullous pemphigoid tense bullae IGG against BPAG 1 and 2 that causesamage to hemidesmosomes and release of basal layer from basement membrane
44
what is stevens johson and what is it a subtype of when does sx occur worst case of this
subtype of erythema multiforme -associated with drug exposure (anticonvulsant or sulfonamides) -sx ocurr 2 weeks to 30 days -involves oral and other mucosa conjuctiva -worst case is toxic epidermal nevrosis skin following off and causes fluid loss risk of infection
45
pink/salmos colored plaques covered with loose silvery scales ( elbow knees scalp and soles of feet) risk for ..... what other sx...
psarosis - hyper proliferation of kerotinocytes risk for artharitis, heat attack and strok other sx are nail changes munro micro abscesses in epidermis and dermal infiltrates
46
what is actinic chieilosisi and what can it lead to
squamous cell carcinoma it is on lip
47
pruritic urple polygonal plana papules and plaques symetric involvment of writs and elbows when does it go away
lichen planus goes away 1-2 years and can have oral lesions type 4 hsr may happen with herpatitis or drug exposure
48
what is wickham striae and what dz is it associated with
leasions coered in reticulated or net like lichen planus
49
interface dermatitis is
between dermis and epidermis angulated inflammation with apoptotic bodies part of lichen planus
50
what is lichen simplex chronicus
thicked epidermius raised erythematous scaly end result of many lesions
51
what is panniculitis
type 4 hypersensitivity recation of fat self limiting erythema nodosum is most common tender nodules involving legs sarcoidosis ulcertie colitis drugs infection but most unknown
52
impetigo is caused by what 2 things Where is this located and what is formed what type of skin infection
1. coagulase postive staphylococci 2. streptococall infection beta hemolytic VERY CONTAGIOUS vesicles sub corneal, nuetrophils beneath honey covered crust pyogenic
53
folliculittis is what kind of infection
pyogenic
54
what is a complication of pyogenic infection
lymphanitis
55
what are koilocytes cells and what dz are they found with... in what layer of cell...
verucae or warts in epidermis epidermal hyperplasia self limited and go away after 2 years NO MALIGNANT POTENTIAL they are vacuolated cells found in the Granular layer
56
Easily ruptured bullae what disease where is it found pathology of dz hsr?
pemphigus vulgaris face scapl axilla trunk and oral lesions supra basal - basal stays attatched to basal membrane patho autoimmune destruction of desmosomes due to IgG agains desmoglein (type 2 HSR) acantholosys of keratonocytes in spinosum causes supravasal bullae
57
tesne bullae patho location
bullous pemphigoid milder than pempigus goin abdomen in elderly and oral immune dsetruction of hemidesmosome due to igG antibodies agains BPAG1 BPAG 2 (hemidesmosome proteins) subepidermal BASAL LAYER DETATCHED FROM BASEMENT MEMBRANE
58
dz associated with gluten sensitivity patho location
bullous dz dermatitis herpetiformis patho ig a at the tipes of dermal paillae causeing subepidermal vesicles located at extensors surface like elbows knees back butt
59
what is ichthyosis
fish scales due to desquamation ( exfoliation) inheritied
60
what causes vertiligo vs cause of albinism
vertiligo destcution of melocytes secondary to autoimmune albinisms looss of pigment due to mutation for ensyme tyrosinase which makes melanin
61
melasma what is who is at risk
hyperpig macules on face due to pregnancy or birth control pills go away after prego
62
ephelis what is
freckels
63
lentigo what is where is it size
linear hyperplasia melanocytes long think rete ridges dont get darker in basal layer size is 5-10 mm
64
morphology of malocytic nevus morphology of dysplastic nevus what nevus mistaken for melanoma
malanocytic 6 mm uniform pigment with defined borders dysplastic : 6 mm macule or plaque irregular border irregular pig and target center (dark center) blue nevus (present at birth)
65
what is evolution of melanocytic nevus
normal junction - pigmented macule not elavated compound - pigment paule elevated dermal 0 intradermal paule - pigment fades elevated
66
melanocytes are in what layer of skin
basal
67
what is dysplastic nevus syndrom gene mutation
multiple nevi 100 irregular shape and color (target dark in the middle) risk of maligment melanoma cdkn2a
68
usually location of squamous cell carcinoma caused by name its morphology
lower lip (actinic keratosis actinic cheilosisi) caused by hpv keratin perls
69
nests of basaloid (deeply basophillic) cells surrounded by palisading nuclei what par of the body is this usually located gene rate of metasis
basal cell carcinoma lower eye lid or face rodent ulce slow rate metases ptch suppressor gene inactive
70
is vertical or horizontal growth worse what about vascularitity what about nuclear atypia
vertical no correlation with vasculature and nuclear atypia
71
what does dermal elastosis mean and what dz does this happen with
damage to collagen in dermis acinic keratosis or actinic cheilosisi cheilitis (premaligment tumor
72
some volcano shapped noduels whats in the center
keratin is in the center keratoacanthoma
73
ptch gene mutation causes what
gorlin syndrom basal cell carcinomas in younger people pamar pits
74
pautrier micro abscess associated with what dz
mycosis funoides t cells cd 4 infiltrate epidermis and ermis to form thes micro abcess can turn into t cell leukemia , sezary syndrom

BASIG q1 (11 decks)

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